Publications

PHRG La Recherche Publications

2021

Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, Breuils-Bonnet S, Tremblay E, Mkannez G, Martineau S, Nadeau V, Roux-Dalvai F, Orcholski M, Jeyaseelan J, Gutstein D, Potus F, Provencher S, Bonnet S, Paulin R, Boucherat O. Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A transcriptomic and Proteomic Approach. Int J Mol Sci. 2021 Mar 15;22(6):2957

Grobs Y, Awada C, Lemay SE, Romanet C, Bourgeois A, Toro V, Nadeau V, Shimauchi K, Orcholski M, Breuils-Bonnet S, Tremblay E, Provencher S, Paulin R, Boucherat O, Bonnet S. Preclinical investigation of Trifluoperazine as a novel therapeutic agent for the treatment of pulmonary arterial hypertensionInt J Mol Sci. 2021 Mar 22(6):2919

Frump A, Albrecht ME, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez BE, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. 17β-estradiol and estrogen receptor-α protect right ventricular function in pulmonary hypertension via BMPR2 and apelinJ Clin Invest. 2021 Mar 15;131(6):129433

Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in PAH. Am J Respir Crit Care Med. 2021 Mar 1;203(5):614-627

Awada C, Grobs Y, Wu WH, Habbout K, Romanet C, Breuils-Bonnet S, Tremblay E, Martineau S, Paulin R, Bonnet S, Provencher S, Potus F, Boucherat O. (R)-Crizotinib Predisposes To and Exacerbates Pulmonary Arterial Hypertension in Animal Models. Eur Respir J. 2021 Jan 14. Online ahead of print

Sommer N, Ghofrani HA, Pak O, Bonnet S, Provencher S, Sitbon O, Rosenkranz S, Hoeper MM, Kiely DG. Current and future treatments of pulmonary arterial hypertension. Br J Pharmacol. 2021 Jan;178(1):6-30

Chelladurai P, Boucherat O, Stenmark K, Kracht M, Seeger W, Bauer UM, Bonnet S, Pullamsetti SS. Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy. Br J Pharmacol. 2021 Jan;178(1):54-71

2020

Potus F, Mai V, Lebret M, Malendant S, Breton-Gagnon E, Lajoie AC, Boucherat O, Bonnet S, Provencher S. Novel insights on the pulmonary vascular consequences of COVID-19. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L277-L288

Omura J, Habbout K, Shimauchi T, Wu WH, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Gagnon K, Mazoyer F, Perron J, Potus F, Lin JH, Zafar H, Kiely DG, Lawrie A, Archer SL, Paulin R, Provencher S, Boucherat O, Bonnet S. Identification of the long non-coding RNA H19 as a new biomarker and therapeutic target in right ventricular failure in pulmonary arterial hypertension. Circulation. 2020 Oct 13;142(15):1464-1484

Veeroju S, Mamazhakypov A, Rai N, Kojonazarov B, Nadeau V, Breuils-Bonnet S, Li L, Weissmann N, Rohrbach S, Provencher S, Bonnet S, Seeger W, Schermuly R, Novoyatleva T. Effect of p53 activation on experimental right ventricular hypertrophy. PLoS One. 2020 Jun 19;15(6):e0234872 (eCollection 2020)

Potus D, Pauciulo MW, Cook EK, Zhu N, Hsieh A, Welch CL, Shen Y, Tian L, Lima P, Mewburn K, D’Arsigny CL, Lutz KA, Coleman AW, Damico R, Snetsinger B, Martin AY, Hassoun PM, Nichols WC, Chung WK, Rauh MJ, Archer SL. Novel mutations and decreased expression of the epigenetic regulator TET2 in pulmonary arterial hypertension. Circulation. 2020 Jun 16;141(24):1986-2000

Potus F, Martin AY, Snetsinger B, Archer SL. Biventricular assessment of cardiac function and pressure-volume loops by closed-chest catheterization in mice. J Vis Exp. 2020 Jun 15;(160)

Provencher S, Potus F, Bonnet S. COVID-19 and the pulmonary vasculature. Pulm Circ. 2020 Jun 10;10(3):2045894020933088 (eCollection Jul-Sep 2020)

Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PDA, Hong Z, Zhao YY, Hindmarch CCT, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL. Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension: a pyruvate dehydrogenase kinase-dependent shift in mitochondrial metabolism promotes right ventricular fibrosis. Circ Res. 2020 Jun 5;126(12):1723-1745

Malenfant S, Brassard P, Paquette M, Le Blanc O, Chouinard A, Bonnet S, Provencher S. Continuous reduction in cerebral oxygenation during endurance exercise in patients with pulmonary arterial hypertension. Physiol Rep. 2020 Mar;8(6):e14389

Lampron MC, Vitry G, Nadeau V, Grobs Y, Paradis R, Samson N, Tremblay E, Boucherat O, Meloche J, Bonnet S, Provencher S, Potus F, Paulin R. PIM1 (Moloney murine leukemia provirus integration site) inhibition decreases the nonhomologous end-joining DNA damage repair signaling pathway in pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):783-801

Nickel NP, Yuan K, Dorfmuller P, Provencher S, Lai YC, Bonnet S, Austin ED, Koch CD, Morris A, Perros F, Montani D, Zamanian RT, de Jesus Perez VA. Beyond the lungs: systemic manifestations of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2020 Jan 15;201(2):148-157

Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB 4th, Provencher S, Zhang L, Uchida S. Clinical values of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases. Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C1-C28

2019

Boucherat O, Paulin R, Provencher S, Bonnet S. New insights into HIMF (hypoxia-induced mitogenic factor)-mediated signaling pathways in pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2451-2453

Bonnet S, Boucherat O, Provencher S, Paulin R. Early evidence for the role of lncRNA TUG1 in vascular remodelling in pulmonary hypertension. Can J Cardiol. 2019 Nov;35(11):1433-1434

Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GP, Szulcek R, Bourgeois A, Lampron MC, Habbout K, Martineau S, Paulin R, Kulikowski E, Jahagirdar R, Schalij I, Bogaard HJ, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Multicenter preclinical validation of BET inhibition for the treatment of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2019 Oct 1;200(7):910-920

Bonnet S, Paulin R. Involvement of PFKFB3 in pulmonary arterial hypertension pathogenesis. Is it all about glycolysis? Am J Respir Crit Care Med. 2019 Sep 1;200(5):532-534

Nadeau V, Bonnet S, Paulin R. Letter by Nadeau et al regarding article ” BMPR2 mutant rats develop pulmonary and cardiac characteristics of pulmonary arterial hypertension’‘. Circulation. 2019 Aug 13;140(7):e286-e287

Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja’a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F. Metabolic syndrome exacerbates pulmonary hypertension due to left heart disease. Circ Res. 2019 Aug 2;125(4):449-466

Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O. Inhibition of CHK1 (Checkpoint kinase 1) elicits therapeutic effects in pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1667-1681

Guimaraes L, Lindenfeld J,  Sandoval J, Bayés-Genis A,  Bernier M,  Provencher S, Rodés-Cabau J. Interatrial shunting for heart failure current evidence and future perspectives. EuroIntervention. 2019 Jun 20;15(2):164-171 

Mai V, Guay CA, Perreault L, Bonnet S, Bertoletti L, Lacasse Y, Jardel S, Lega JC, Provencher S. Extended anticoagulation for VTE: a systematic review and meta-analysis. Chest. 2019 Jun;155(6):1199-1216

Sofianopoulou E, Kaptoge S, Gräf S, Hadinnapola C, Treacy CM, Church C, Coghlan G, Gibbs JSR, Haimel M, Howard LS, Johnson M, Kiely DG, Lawrie A, Lordan J, MacKenzie Ross RV, Martin JM, Moledina S, Newnham M, Peacock AJ, Price LC, Rhodes CJ, Suntharalingam J, Swietlik EM, Toshner MR, Wharton J, Wilkins MR, Wort SJ, Pepke-Zaba J, Condliffe R, Corris PA, Di Angelantonio E, Provencher S, Morrell NW. Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis. Eur Respir J. 2019 May 30;53(5):1801429

Omura J, Bonnet S, Kutty S. Right ventricular and pulmonary vascular changes in pulmonary hypertension associated with left heart diseaseAm J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1144-H1145

Mai V, Bertoletti L, Cucherat M, Jardel S, Grange C, Provencher S, Lega JC. Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis. PLoS One. 2019 Apr 1;14(4):e0214134

Tanguay VF, Babin C, Giardetti G, Sohier-Poirier C, Ménard-Cholette V, Ranchoux B, Ruffenach G, Montani D, Bonnet S, Provencher S. Enhanced pulmonary artery radiodensity in Pulmonary Arterial Hypertension: A sign of early calcification? Am J Respir Crit Care Med. 2019 Mar 15;199(6):799-802

Barba T, Fort R, Cottin V, Provencher S, Durieu I, Jardel S, Hot A, Reynaud Q, Lega JC. Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systemaic review and meta-analysisAutoimmun Rev. 2019 Feb;18(2):113-122

Lai YC, Provencher S, Goncharova EA. TAKling GDF-15 and skeletal muscle atrophy in pulmonary hypertension: are we there yet? Thorax. 2019 Feb; 74(2): 103-105

Humbert M, Guignabert C, Bonnet S, Dorfmüller P, Klinger JR, Nicolls MR, Olschewski AJ, Pullamsetti SS, Schermuly RT, Stenmark KR, Rabinovitch M. Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. Eur Respir J. 2019 Jan 24;53(1):1801887

Nathan SD, Barbera JA, Gaine SP, Harari S, Martinez FJ, Olschewski H, Olsson KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Seeger W. Pulmonary hypertension in chronic lung disease and hypoxiaEur Respir J. 2019 Jan 24; 53(1):1801914

Bussières JS, Moreault O, Couture EJ, Provencher S. Optimizing lung collapse with a bronchial blocker: it’s not what you use, but how you use it, part II. J Cardiothorac Vasc Anesth. 2019 Jan; 33(1):255

2018

Bourgeois A, Omura J, Habbout K, Bonnet S, Boucherat O. Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets. Int J Biochem Cell Biol. 2018 Nov;104:9-13

Guay CA, Morin-Thibault LV, Bonnet S, Lacasse Y, Lambert C, Lega JC, Provencher S. Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis. Plos One. 2018 Oct 11;13(10):e0204610

Couture EJ, Provencher S, Denault AY. Management of severe Pulmonary Hypertensive Disease for surgical and nonsurgical procedures. Int Anesthesiol Clin . Fall 2018;56(4):e28-e55

Bonnet S, Paulin R, Boucherat O. Small SeP or giant leap for Pulmonary Hypertension Research? Circulation. 2018 Aug 7;138(6):624-626

Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunhan-Snary K, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL. Epigenetic dysregulation of the Drp1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension: mechanistic and therapeutic implications. Circulation. 2018 Jul 17;138(3):287-304

Adao R, Mendes-Ferreira P, Santos-Ribeiro D, Maia-Rocha C, Pimentel L, Pinto C, Mulvaney EP, Reid HM, Kinsella BT, Potus F, Breuils-Bonnet S, Rademaker MT, Provencher S, Bonnet S, Leite-Moreira A, Bras-Silva C. Urocortin-2 improves right ventricular function in pulmonary arterial hypertension.Cardiovasc Res. 2018 Jul 1;114(8):1165-1177

Boucherat O, Peterlini T, Bourgeois A, Nadeau V, Breuils-Bonnet S, Boilet-Molez S, Potus F, Meloche J, Chabot S, Lambert C, Tremblay E, Chae YC, Altieri DC, Sutendra G, Michelakis ED, Paulin R, Provencher S, Bonnet SMitochondrial HSP90 accumulation promotes vascular remodeling in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2018 Jul 1;198(1):90-103

Brittain EL,Thenappan T,  Maron BA,  Chan SY, Austin ED, Spiekerkoetter E, Bogaard HJ, Guignabert C,  Paulin R, Machado RF,  Yu PB .Update in pulmonary vascular disease 2016 and 2017Am J Respir Crit Care Med. 2018  Jul 1;198(1):13-23

Belzile D, Jacquet S, Bertoletti L, Lacasse Y, Lambert C,Lega J.C, Provencher S. Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: a meta-analysis of the management outcome studies. J Thromb Haemost. 2018 Jun;16(6):1107-1120

Lajoie AC, Bonnet S, Lacasse Y, Lega JC, Provencher S. Interpreting risk reduction in clinical trials for pulmonary arterial hypertension. Eur Respir Rev. 2018 May 15;27(148):180020

Agarwal S, Spiekerkoetter E, Austin ED, de Jesus Perez V, Dezfulian C, Maron BA, Ryan JJ, Starks MA, Yu PB, Bonnet S, Perman SM. Career Development of Young Physician-Scientists in the cardiovascular sciences: Perspective and advice from the early career committee of the Cardiopulmonary, Critical Care, and Resuscitation of the American Heart AssociationCirc Res. 2018 May 11;122(10):1330-1333

Lajoie AC, Guay CA, Lega JC, Lauzière G, Simard S, Lambert C, Lacasse Y, Bonnet S, Provencher S. Trial duration and risk reduction in combination therapy trials for pulmonary arterial hypertension: A systematic review. Chest. 2018 May;153(5):1142-1152

Morin-Thibault LV, Wiseman D, Fortin M, Couture C, Provencher S. Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report. Pulm Circ. 2018 Apr-Jun;8(2):2045893218754853

Kuebler WM, Bonnet S, Tabuchi A. Inflammation and autoimmunity in pulmonary hypertension- is there a role for endothelial adhesion molecules? Pulm Circ. 2018 Apr-Jun;8(2):2045893218757596

Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S. Standards and methodological rigor in pulmonary arterial hypertension preclinical and translational researchCirc Res. 2018 Mar 30;122(7):1021-1032

Bonnet S and Boucherat O. The ROS controversy in hypoxic pulmonary hypertension revisited. Eur Respir J. 2018 Mar 8;51(3):1800276

Frump AL, Bonnet S, de Jesus Perez VA, Lahm T. The emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertensionAm J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L443-L460

Boucherat O, Provencher S, Bonnet S.Therapeutic Value of ASK1 in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197(3):284-286

Bourgeois A, Lambert C, Habbout K, Paquet-Marceau S, Trinh I, Breuils-Bonnet S, Paradis R, Nadeau V, Paulin R, Provencher S, Bonnet S, Boucherat O. FOXM1 promotes pulmonary smooth muscle cell expansion in pulmonary arterial hypertension. J Mol Med (Berl). 2018 Feb;96(2):223-235

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils-Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM. Loss of SMAD3 promotes vascular remodeling in pulmonary arterial hypertension via MRTF disinhibition. Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260

Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, Paulin R, Bonnet S, Provencher S. Dual ETA/ETBblockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension. Pulm Circ. Jan-Mar 2018;8(1):2045893217741429

Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ. Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscpae (2017 Grover Conference Series)Pulm Circ. Jan-Mar 2018;8(1):2045893217752912

Clemenceau A, Boucherat O, Landry-Truchon K, Lamontagne M, Biardel S, Joubert P, Gobeil S, Secco B, Laplante M, Morissette M, Obeidat M, Timens W, Jeannotte L, Bossé Y. Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung. Int J Dev Biol. 2018;62(11-12):857-864

2017

Malenfant S, Brassard P, Paquette M, Le Blanc O, Chouinard A, Nadeau V, Allan PD, Tzeng YC, Simard S, Bonnet S, Provencher S. Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension. J Am Heart Assoc. 2017 Oct 12;6(10):e006126

Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L. HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 1; 144(19):3547-3561

Meloche J, Lampron MC, Nadeau V, Maltais M, Potus F, Lambert C, Tremblay E, Vitry G, Breuils-Bonnet S, Boucherat O, Charbonneau E, Provencher S, Paulin R, Bonnet S.Implication of inflammation and epigenetics Readers in Coronary Artery Remodeling in patients with pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1513-1523

Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S. HDAC6: A novel histone deacetylase implicated in pulmonary arterial hypertension. Sci Rep. 2017 Jul 3;7(1):4546

Lajoie AC, Bonnet S, Provencher S. Clinical trial research in focus: improving drug development ad trial design in pulmonary arterial hypertensionLancet Respir Med. 2017 Jul;5(7):544-546

Harel F, Langleben D, Provencher S, Fournier A, Finnerty V, Nguyen QT, Letourneau M, Levac X, Abikhzer G, Guimond J, Mansour A, Guertin MC, Dupuis J. Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension: a phase II safety and proof of principal trialEur J Nucl Med Mol Imaging. 2017 Jul;44(7):1136-1144

Samson N, Paulin R. Epigenetics, inflammation and metabolism in right heart failure associated with pulmonary hypertensionPulm Circ. Jul-Sep 2017;7(3):572-587

Perros F, Humbert M, Nazzareno G, Simmoneau G, Bogaard HJ, de Man F, Antigny F, Provencher S, Bonnet S, Galiè N, Humbert M.. Use of beta-blockers in pulmonary hypertensionCirc Heart Fail. 2017 Apr;10(4):e003703

Lajoie AC, Bonnet S, Provencher S. Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challengesPulm Circ. 2017 Apr-Jun;7(2):312-325

Boucherat O, Vitry G, Trinh I, Paulin R, Provencher S, Bonnet S. The cancer theory of pulmonary arterial hypertension. Pulm Circ. 2017 Apr-Jun;7(2):285-299

Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M. Translating research into improved patient care in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2017 Mar 1;195(5):583-595

Hong Z, Chen K, Dasgupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Archer SL. miR-138 and miR-125 downregulate MCU, causing pulmonary arterial hypertension’s cancer phenotype. Am J Respir Crit Care Med. 2017 Feb 15;195(4):515-529

Chun HJ, Bonnet S, Chan SY. Translating microRNA biology in pulmonary hypertension: it will take more than ”miR” words. Am J Respir Crit Care Med. 2017 Jan 15;195(2):167-178

Boucherat O, Landry-Truchon K, Aoidi R, Houde N, Nadeau V, Charron J, Jeannotte L. Lung development requires and active ERK/MAPK pathway in the lung mesenchymeDev Dyn. 2017 Jan;246(1):72-82

2016

Ruffenach*, Chabot S*, Tanguay VF, Courboulin A, Boucherat O, Potus f, Meloche J, Pflieger A, Breuils-Bonnet S, Nadeau V, Paradis R, Girerd B, Hautefort A, Montani D, Fadel E, Dorfmuller P, Humbert M, Perros F, Paulin R, Provencher S, Bonnet S. RUNX2 in proliferative and calcified vascular lesions seen in pulmonary arterial hypertension. Am J Resp Crit Care Med. 2016 Nov15;194(10):1273-1285

Boucherat O, Bonnet Sand Paulin R. The HIPPO-thesis of pulmonary HYPERtension. Am J Resp Crit Care Med. 2016 Oct 1;194(7):787-789

Ryerson C, Camp PG, Eves ND, Schaeffer M, Syed N, Dhillon S, Jensen D, Maltais F, O’Donnell DE, Raghavan N, Roman M, Stickland MK, Assayag D, Bourbeau J, Dion G, Fell CD, Hambly N, Johannson KA, Kalluri M, Khalil N, Kolb M, Manganas H, Moran-Mendoza O, Provencher S, Ramesh W, Douglass Rolf J, Wilcox PG, Guenette JA. High oxygen delivery to preserve exercise capacity in Idiopathic Pulmonary Fibrosis treated with Nintedanib, Methodology of the HOPE-IPF StudyAnn Am Thorac Soc. 2016 Sep;13(9):1640-7

Ranchoux B*, Meloche J*, Paulin R, Boucherat O, Provencher S, Bonnet S. DNA damage and pulmonary hypertension. Int J Mol Sci . 2016 Jun 22;17(6):990

Bonnet Sand Provencher S. Shear stress maladaptation in pulmonary arterial hypertension: an ageless concept. Am J Resp Crit Care Med. 2016 Jun 15;193(12):1331-2

Boucherat O, Jeannotte L, Hadchouel A, Delacourt C, Benachi A. Pathomechanismms of congenital cystic lung diseases: Focus on congenital cystic adenomatoid malformation and pleuropulmonary blastoma. Respir Rev. 2016 Jun;19:62-8

Antigny F, Hautefort A, Meloche J, Belacel-Ouari M, Manoury B, Rucker-Martin C, Péchoux C, Potus F, Nadeau V, Tremblay E, Ruffenach G, Bourgeois A, Dorfmuller P, Breuils-Bonnet S, Fadel E, Ranchou B, Jourdon P, Girerd B, Montani D, Provencher S, Bonnet S, Simmoneau G, Humbert M, Perros F. Potassium-channel subfamily K-member 3 (KCNK3) contributes to the development of pulmonary arterial hypertension. Circulation. 2016 April 5;133 (14):1371-85

Lajoie AC, Lauzière G, Lega JC, Lacasse Y, Martin S, Simard S, Bonnet S, Provencher S. Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis. Lancet Respi Med. 2016 Apr;4(4):291-305

Kinnaird A, Dromparis P, Salee B, Gurtu V, Watson K, Paulin R, Zervopulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED. Metabolic Modulation od Clear-cell Renal cell carcinoma with Dicholoroacetate, an inhibitor of pyruvate dehydrogenase kinaseEur Urol. 2016 Apr;69(4):734-744

Boucherat O, Morissette MC, Provencher S, Bonnet S, Maltais F. Bridging lung development with COPD: Relevance of developmental pathways in COPD pathogenesis. Am J Respir Crit Care Med. 2016 Feb 15;193(4):362-75

Courboulin A, Ranchoux B, Cohen-Kaminsky S, Perros F, Bonnet S. MicroRNA networks in pulmonary arterial hypertension: share mechanisms with cancer? Curr Opin Oncol. 2016 Jan;28(1):72-82

2015

Malenfant S, Potus F, Mainguy V, Leblanc È, Malenfant M, Ribeiro F, Saey D, Maltais F, Bonnet S, Provencher S. Impaired skeletal muscle oxygenation and exercise tolerance in pulmonary hypertensionMed Sci Sports Exerc. 2015 nov;47(11):2273-82

Perros F, Bonnet S. Bone morphogenetic protein receptor type II and inflammation are bringing old concepts into the new pulmonary arterial hypertension world.Am J Respir Crit Care Med. 2015 Oct 1;192(7):777-9

Fortin M, Turgeon PY, Nadreau É, Grégoire P, Maltais LG, Sénéchal M, Provencher S, Maltais F. Prognostic value of oxygen kinetics during recovery from cardiopulmonary exercise testing in patients with chronic heart failure.Can J Cardiol. 2015 Oct;31(10):1259-65

Boucherat O, Chabot S, Antigny F, Perros F, Provencher S, Bonnet S.Potassium channels in pulmonary arterial hypertension. Eur Respir J. 2015 Oct;46(4):1167-77

Meloche J, Le Guen M, Potus F, Vinck J, Ranchoux B, Johnson I, Antigny F, Tremblay E, Breuils-Bonnet S, Perros F, Provencher S,Bonnet S. MiR-223 reverses experimental pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2015 Sep 15;309(6):c363-72

Potus F, Ruffenach G, Dahou A, Thebault C, Breuils-Bonnet S, Tremblay È, Nadeau V, Paradis R, Graydon C, Wong R, Johnson I, Paulin R, Lajoie AC, Perron J, Charbonneau E, Joubert P, Pibarot P, Michelakis ED, Provencher S, Bonnet S. Downregulation of miR-126 contributes to the failing right ventricle in pulmonary arterial hypertension. 2015 Sep 8;132(10):932-43

Boucherat O, Landry-Truchon K, Bérubé-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L. Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. 2015 Sep 1;142(17):22981-95

Meloche J, Potus F, Vaillancourt M, Bourgeois A, Johnson IH, Deschamps L, Chabot S, Ruffenach GN, Henry S, Breuils-Bonnet S, Tremblay È, Nadeau V, Lambert CM, Paradis R, Provencher S, Bonnet S. Bromodomain Containing Protein-4: The epigenetic origin of pulmonary arterial hypertension.Circ Res. 2015 Aug 28;117(6):525-35

Labbé C, Beaudoin S, Martel S, Delage A, Drapeau C,Provencher S. Diagnostic yield of non-guided flexible bronchoscopy for peripheral pulmonary neoplasia. Thorac Cancer . 2015 Jul;6(4):517-23

Boucherat O, Bonnet S. NOGGIN: a new therapeutic target for PH? Focus on “Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and TRPC channels”.Am J Physiol Cell Physiol. 2015 Jun1;308(11):C867-8

Paulin R, Michelakis ED. Addressing complexity in pulmonary hypertension: The FoxO1 caseCirc Res. 2015 May 22;116(11):1732-5

Courboulin A, Kang C, Baillard O, Bonnet S, Bonnet P. Increasing pulmonary artery pulsatile flow improves hypoxic pulmonary hypertension in pigletsJ Vis Exp . 2015 May 11;(99):e52571

Sutendra G, Bonnet S. The iron paradigm of pulmonary arterial hypertension: popeye knows best.Circ Res. 2015 May 8;116(10):1636-8

Malenfant S, Potus F, Fournier F, Breuils-Bonnet S, Pflieger A, Bourassa S, Tremblay È, Nehmé B, Droit A, Bonnet S, Provencher S. Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension.J Mol Med (Berl). 2015 May;93(5):573-84

Gagnon P, Casaburi R, Saey D, Porszasz J, Provencher S, Milot J, Bourbeau J, O’Donnell DE, Maltais F. Cluster analysis in patients with GOLD 1 Chronic Obstructive Pulmonary Disease.PLoS One . 2015 Apr 23;10(4):e0123626

Provencher S, Granton JT. Current treatment approaches to pulmonary arterial hypertension.Can J Cardiol. 2015 Apr;31(4):460-77

Vaillancourt M, Ruffenach G, Meloche J, Bonnet S. Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension.Can J Cardiol. 2015 Apr;31(4):407-15

Ferland N, Couture C, Provencher S. Near-fatal haemoptysis as presentation of a giant intralobar pulmonary sequestration.Eur Respir Rev. 2015 Mar;24(135):155-6

Provencher S, Paruchuru P, Spezzi A, Waterhouse B, Gomberg-Maitland M, on behalf of the pH12 Flolan reformulation study group. Quality of Life, Safety and Efficacy profile of thermostable Flolan in pulmonary arterial hypertensionPLoS One . 2015 Mar 20;10(3):e0120657

Fillmore N, Huqi A, Jaswal JS, Mori J, Paulin R, Haromy A, Onay-Besikci A, Ionescu L, Thébaud B, Michelakis E, Lopaschuk GD. Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survivalPLoS One. 2015 Mar 13;10(3):e0120257

Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy AS, Provencher S, Bonnet S, Michelakis E. A miR-208-Mef2 axis drives the de-compensation of right ventricular function in Pulmonary HypertensionCirc Res . 2015 Jan 2;116(1):56-69

Meloche J, Paulin R, Provencher S, Bonnet S. Therapeutic potential of microRNA modulation in pulmonary arterial hypertension. Curr Vasc Pharmacol. 2015;13(3):331-40

Antigny F, Ranchou B, Nadeau V, Edmund L, Bonnet S, Perros F. A simple method to assess in vivoproliferation in lung vasculature with EdU: The case of MMC-induced PVOD in rat. Anal Cell Pathol (Amst). 2015;2015:326385

Boucherat O, Potus F, Bonnet S. microRNA and Pulmonary HypertensionAdv Exp Med Biol. 2015;888:237-52

Potus F, Le Guen M, Provencher S, Meloche J, Bonnet S. DNA damage at the dawn of micro-RNA pathway impairment in pulmonary arterial hypertension. RNA & DISEASE Vol 2 (2015)

2014

Paulin R, Dromparis P, Sutendra G, Gurtu V, Zervopoulos S, Bowers L, Haromy A, Webster L, Provencher S, Bonnet S, Michelakis ED. Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humansCell Metab. 2014 Nov 4;20(5):827-839

Rival G, Lacasse Y, Martin S, Bonnet S, Provencher S. Effect of pulmonary arterial hypertension specific therapies on health-related quality of life: a systematic review. Chest. 2014 Sep;146(3):686-708

Chaouat A, Sitbon O, Mercy M, Ponçot-Mongars R,Provencher S, Guillaumot A, Gomez E, Selton-Suty C, Malvestio P, Regent D, Paris C, Hervé P, Chabot F. Pronostic value of exercise cardiac index in idiopathic, familial and anorexigen-associated pulmonary arterial hypertension. Eur Respir J. 2014 Sep;44(3):704-13

Mainguy V, Malenfant S, Neyron AS, Saey D, Maltais F, Bonnet S, Provencher S. Alternatives to the six-minute walk test in pulmonary arterial hypertension. PLoS One. 2014 Aug 11;9(8):e103626

Potus F, Malenfant S, Graydon C, Mainguy V, Tremblay E, Breuils-Bonnet S, Ribeiro F, Porlier A, Maltais F, Bonnet S, Provencher S. Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 Aug 1;190(3):318-28

Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, Breuils-Bonnet S, Mai D, Navab K, Ross D, Navab M, Provencher S, Fogelman AM, Bonnet S, Reddy ST, Eghbali M. Apolipoprotein A-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p. Circulation. 2014 Aug 26;130(9):776-85

Meloche J, Pflieger A, Vaillancourt M, Graydon C, Provencher S,Bonnet S. miRNAs in PAH: biomarker, therapeutic target or both? Drug Discov Today. 2014 Aug;19(8):1264-9

Sutendra G, Kinnaird A, Dromparis P, Paulin R, Stenson TH, Haromy A, Hashimoto K, Zhang N, Flaim E, Michelakis ED. A nuclear pyruvate dehydrogenase complex is important for the generation of actyl-CoA and histone acetylation. Cell. 2014 Jul 3;158(1):84-97

Paulin R, Michelakis ED. The metabolic theory of pulmonary arterial hypertensionCirc Res. 2014 Jun 20;115(1):148-64

Potus F, Graydon C, Provencher S, Bonnet S. Vascular remodeling process in pulmonary arterial hypertension with focus on miR-204 and miR126Pulm Circ. 2014 Jun;4(2):175-84

Dromparis P, Sutendra G, Paulin R, Proctor S, Michelakis ED, McMurtry MS. Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cellsJ Mol Med (Berl). 2014 May;92(5):497-507

Meloche J, Pflieger A, Vaillancourt M, Paulin R, Potus F, Zervopoulous S, Graydon C, Courboulin A, Breuils-Bonnet S, Tremblay E, Couture C, Michelakis ED, Provencher S, Bonnet S. Role for DNA damage signaling in pulmonary arterial hypertension. Circulation. 2014 Feb 18;129(7):786-97

Paulin R, Meloche J, Courboulin A, Lambert C, Haromy A, Courchesne A, Bonnet P, Provencher S, Michelakis ED, Bonnet S. Targeting cell motility in pulmonary arterial hypertension. Eur Respir J. 2014 Feb;43(2):531-44

Gagnon P, Lemire BB, Dubé A, Saey D, Porlier A, Croteau M, Provencher S, Debigaré R, Maltais F. Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD. Respir Res. 2014 Jan 17;15(1):4

2013

Vonk Noordegraaf A, Haddad F, Chin KM, Forfia Pr, Dawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel N, Hassoun PM. Right Heart Adaptation to Pulmonary Arterial Hypertension: Physiology and Pathobiology. J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D22-33

Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED. A metebolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated sate in pulmonary hypertensionJ Mol Med (Berl). 2013 Nov;91(11):1315-27

Chemla D, Castelain V, Hoette S, Creuze N, Provencher S, Zhu K, Humbert M, Herve P. Strong linear relationship between heart rate and mean pulmonary artery pressure in exercising patients with severe precapillary pulmonary hypertensionAm J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H769-77

Mainguy V*, Malenfant S*, Neyron AS*, Bonnet S, Maltais F, Saey D, Provencher S. Repeatability and responsiveness of exercise tests in pulmonary arterial hypertensionEur Respir J. 2013 Aug;42(2):425-34

Dromparis P, Paulin R, Sutendra G, Qi AC, Bonnet S, Michelakis ED. Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary hypertensionCirc Res. 2013 Jul 5;113(2):126-36

Boucherat O, Montaron S, Bérubé-Simard FA, Aubin J, Philippidou P, Wellik DM, Dasen JS, Jeannotte L.Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L817-30

Boucherat O, Boczkowski J, Jeannotte L, Delacourt C. Cellular and molecular mechanisms of goblet cell metaplasia in the respiratory airways. Exp Lung Res. May-Jun 2013;39(4-5):207-16

Malenfant S*, Neyron AS*, Paulin R, Potus F*, Meloche J, Provencher S, Bonnet S. Signal transduction pathways in the development of pulmonary arterial hypertensionPulm Circ. 2013 Apr;3(2):278-93

Malenfant S, Margaillan G, Loehr J, Bonnet S, Provencher S. The emergence of new therapeutic targets in pulmonary arterial hypertension: from now to near future. Expert Rev Respir Med. 2013 Feb;7(1):43-55

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay E, Biardel S, Racine C, Couture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.Critical Role of the Advanced Glycation Endproducts Receptor in Pulmonary Arterial Hypertension Ethiology. J Am Heart Assoc. 2013 Jan 16;2(1):e005157

Dromparis P, Paulin R, Stenson TH, Haromy A, Sutendra G, Michelakis ED. Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. Circulation. 2013 Jan 1; 127(1):115-25

Renard S, Paulin R, Breuils-Bonnet S, Simard S, Pivarot P, Bonnet S,Provencher S. Pim-1: a new biomarker in pulmonary arterial hypertension. Pulm Circ. 2013 Jan;3(1):74-81

Coates AL, Graham BL, McFadden RG, McParland C, Moosa D, Provencher S, Road J.Spirometry in Primary Care: a Canadian Thoracic Society Position Paper. Can Respir J. Jan-Feb 2013;20(1):13-21

Borel B, Provencher S, Saey D, Maltais F. Responsiveness of various exercise-testing protocols to therapeutic interventions in COPDPulm Med. 2013;2013:410748

Provencher S, Renard S, Rival G. Exploration pulmonaire par cathétérisme droit. EMC-Pneumologie 2013; 10(1): 1-10. [Article 6-000-F-20]

Meloche J*, Renard S*, Provencher S, Bonnet S. Anti-inflammatory and Immunosuppressive Agents in PAH. Handb Exp Pharmacol . 2013;218:437-76

Provencher S, Mainguy V*, Simon M, Martel M. Physiopathologie des maladies vasculaires pulmonaires. Presses de l’Université Laval 2013

2012

Gagnon P, Saey D,Provencher S, Milot J, Bourbeau J, Tan, WC, Martel S, Maltais F. Walking exercise response to bronchodilation in mild COPD: A randomized trial. Respir Med. 2012 Dec;106(12):1695-705

Mainguy V, Provencher S. Le test de marche: un outil essentiel en pneumologie. La Lettre du Pneumologue • Vol. XV – n°6 – novembre-décembre 2012

Paulin R, Meloche J, Bonnet S. STAT3 signaling in pulmonary arterial hypertensionJAKSTAT. 2012 Oct 1;1(4):223-33

Gagnon P, Bussières J, Ribeiro F, Gagnon S, Saey D, Gagné N,Provencher S, Maltais F. Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012 Oct 1;186(7):606-15

Courboulin A, Barrier M, Perreault T, Bonnet P, Tremblay VL, Paulin R, Tremblay E, Lambert C, Jacob MH, Bonnet SN, Provencher S, Bonnet S.  Plumbagin reverses proliferation and resistance to apoptosis in experimental PAHEur Respir J. 2012 Sep;40(3):618-29

Barrier M, Meloche J, Jacob MH, Courboulin A, Provencher S, Bonnet S. Today’s and tomorrow’s imaging and circulating biomarkers for pulmonary arterial hypertensionCell Mol Life Sci. 2012 Sep;69(17):2805-31

Paulin R, Michelakis ED. The estrogen puzzle in pulmonary arterial hypertensionCirculation. 2012 Aug 28;126(9):1016-9

Boucherat O, Chakir J, Jeannotte L. The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airwaysBiol Open. 2012 Jul 15;1(7):677-91

Mainguy V, Girard D, Maltais F, Saey D, Milot J, Sénéchal M, Poirier P, Provencher S. Effects of Bisoprolol on respiratory function and exercise capacity in COPDAm J Cardiol. 2012 Jul 15;110(2):258-63

Gendronneau G, Boucherat O, Aubin J, Lemieux M, Jeannotte L. The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts. Endocrinology. 2012 Mar;153(3):1484-97

Deschenes D, Provencher S, Cormier Y. Framer’s Lung-Induced Hypersensitivity Pneumonitis Complicated By ShockRespir Care. 2012 Mar;57(3):464-6

Bédard ME, Brouillard C, Pepin V,Provencher S, Milot J, Lacasse Y, Leblanc P, Maltais, F. Tiotropium improves walking endurance in patients with chronic obstructive pulmonary diseaseEur Respir J. 2012 Feb;39(2):265-71

Provencher S, Mainguy V. Exercise testing in Pulmonary Arterial Hypertension. Pulmonary Vascular Disorders. Prog Respir Res. Basel, Karger, 2012, vol 41, pp 37–47

Provencher S, Bonnet S. Pulmonary arterial hypertension research: Why does it take so long? How can I contribute? Connections. 2012; 3(2): 26-7

2011

Franco-Montoya ML, Boucherat O, Thibault C, Chailley-Heu B, Incitti R, Delacourt C, Bourbon JR. Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development. Genomics. 2011 Nov 7;43(21):1226-40

Paulin R, Meloche J, Jacob MH, Bisserier M, Courboulin A, Bonnet S. Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertensionAm J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1798-809

Paulin R, Courboulin A, Barrier M, Bonnet S. From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension. J Mol Med (Berl). 2011 Nov;89(11):1089-101

Belmokhtar K, Bourguignon T, Worou ME, Khamis G, Bonnet P, Domenech J, and Eder V.Regeneration of three layers vascular wall by using BMP2-treated MSC involving HIF-1alpha and Id1 expressions through JAK/STAT pathwaysStem Cell Rev Rep. 2011 Nov;7(4):847-59

Courboulin A, Tremblay VL, Barrier M, Meloche J, Jacob MH, Chapolard M, Bisserier M, Paulin R, Lambert C, Provencher S,Bonnet S. Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertensionRespir Res. 2011 Sep 27;12(1):128

Meloche J, Paulin R, Courboulin A, Lambert C, Barrier M, Bonnet P, Bisserier M, Roy M, Sussman MA, Agharazii M, Bonnet S. RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2114-24

Sutendra G, Dromparis P, Bonnet S, HaromyA, McMurtry MS, Bleackley C, Michelakis E. Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertensionJ Mol Med (Berl). 2011 Aug;89(8):771-83

Sutendra G; Bonnet Set al. The role of Nogo and the mitochondria-endoplasmic reticulum unit and the pathogenesis of pulmonary hypertensionSci Transl Med. 2011 Jun 22;3(88):88ra55

Provencher S, Chemla D, Hervé P. Hémodynamique de repos et d’effort dans l’hypertension artérielle pulmonaire / Resting and exercise hemodynamics in pulmonary arterial hypertension. Presse Med. 2011 Apr;40 Suppl 1:1S28-38

Paulin R, Courboulin A, Meloche J, Mainguy V, Dumas de la Roque E, Saksouk N, Côté J,Provencher S, Sussman MA, Bonnet S. Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertensionCirculation. 2011 Mar 22;123(11):1205-15

Courboulin A, Paulin R, Giguère NJ, Saksouk N, Perreault T, Meloche J, Paquet ER, Biardel S, Provencher S, Côté J, Simard MJ,Bonnet S. Role for miR-204 in human pulmonary arterial hypertension. J Exp Med. 2011 Mar 14;208(3):535-48

Deslauriers J, Ugalde P, Miro S, Ferland S, Bergeron S, Lacasse Y, Provencher S.Adjustments in cardiorespiratory function after pneumonectomy: results of the pneumonectomy projectJ Thorac Cardiovasc Surg. 2011 Jan;141(1):7-15

Deslauriers, J, Ugalde P, Miro S, Deslauriers D, Ferland S, Bergeron S, Lacasse Y, Provencher S.Long-term physiologic consequences of pneumonectomySemin Thorac Cardiovasc Surg. Autumn 2011;23(3):196-202

Mainguy V,Provencher S, Maltais F, Malenfant S, Saey D. Assessment of Daily Life Physical activities in Pulmonary Arterial HypertensionPLoS One. 2011;6(11):e27993

Paulin R, Barrier M, Bonnet S. New Therapeutics for pulmonary arterial hypertension: do gene therapies have translational values? Clin Invest. 2011;1(3):363-366.

Paulin R, Dumas De La Roque E, Bonnet S. DHEA and vascular health and fonctions. DHEA (dehydroepiandrosterone) in Human Health and Aging, DHEA chapters from Dr. Ronald Watson. editor: Taylor and Francis Group 2011. ISBN 9781439838839

2010

Bédard ME, Marquis K, Poirier P, Provencher S. Reduced Heart Rate Variability in Patients With Chronic Obstructive Pulmonary Disease independent of anticholinergic or ß-agonist medications. COPD. 2010 Dec;7(6):391-7

Mehta S, Helmersen D, Provencher S, Hirani N, Rubens FD, De Perrot M, Blostein M, Boutet K, Chandy G, Dennie C, Granton J, Hernandez P, Hirsch AM, Laframboise K, Levy RD, Lien D, Martel S, Shoemaker G, Swiston J, Weinkauf J; for the Canadian Thoracic Society Pulmonary Vascular Disease – CTEPH CPG Development Committee; Canadian Thoracic Society Canadian Respiratory Guidelines Committee. Diagnostic evaluation and management of chronic thromboembolic pulmonary hypertension: A clinical practice guideline. Can Respir J. Nov-Dec 2010;17(6):301-34

Lambert CM, Roy M, Robitaille GA, Richard DE, Bonnet S.HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism. Cardiovasc Res. 2010 Oct 1;88(1):196-204

Lambert CM, Roy M, Meloche J, Robitaille GA, Agharazii M, Richard DE, Bonnet STumor necrosis factor inhibitors as novel therapeutic tools for vascular remodeling diseasesAm J Physiol Heart Circ Physiol. 2010 Oct;299(4):H995-1001

Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension. J Cardiopulm Rehabil Prev. Sep-Oct 2010;30(5):319-23

Sutendra G, Bonnet S, Rochefort G, Haromy A, Folmes KD, Lopaschuk GD, Dyck JR, Michelakis ED. Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertensionSci Transl Med. 2010 Aug 11;2(44):44ra58

Laviolette L, Lands LC, Dauletbaev N, Saey D, Milot J, Provencher S, LeBlanc P, Maltais F. Combined effect of dietary supplementation with pressurized whey and exercise training in COPD: a randomized controlled double-blind pilot studyJ Med Food. 2010 Jun;13(3):589-98

Boucherat O, Franco-Montoya ML, Delacourt C, Martinovic J, Masse V, Elie C, Thébaud B, Benachi A, Bourbon JR. Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficienccy that occurs despite enhanced angiopoietin-2 and VEGFAm J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L849-56

Coulombe Y, Lemieux M, Moreau J, Aubin J, Joksimovic M, Bérubé-Simard FA, Tabariès S, Boucherat O, Guillou F, Larochelle C, Tuggle CK, Jeannotte L. Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryoPLoS One. 2010 May 12;5(5):e10600

Dumas de la Roque E, Savineau JP, Bonnet S. Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertensionPharmacol Ther. 2010 May;126(2):186-99

Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Peripheral Muscle Dysfunction in Idiopathic Pulmonary Arterial HypertensionThorax. 2010 Feb;65(2):113-7

2009

Van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt, G, Archer SL, Thébaud B. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in ratsAm J Respir Crit Care Med. 2009 Dec 1;180(11):1131-42

Lega JC, Lacasse Y, Lakhal L, Provencher S.   Natriuetic peptides and troponins in pulmonary embolism: a meta-analysisThorax. 2009 Oct;64(10):869-75

Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, Nagendran J, Haromy A, Dyck JR, Michelakis ED. Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axisCirculation. 2009 Sep 29;120(13):1231-40.

Gagnon P, Saey D, Vivodtzev I, Laviolette L, Mainguy V, Milot J, Provencher S, Maltais F.Impact of pre-induced quadriceps fatigue on exercise response in chronic obstructive pulmonary disease and healthy subjectsJ Appl Physiol (1985). 2009 Sep;107(3):832-40

McLaughlin VV, Badesch DB, Delcroix M, Fleming TR, Gaine SP, Galié N, Gibbs JSR, Kim NH, Oudiz RJ, Peacock A, Provencher S, Sitbon O, Tapson VF, Seeger W. End points and clinical trial design in PAHJ Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S97-107.

Grünig E, Weissmann S, Ehlken N,Fijalkowska A, Fischer C, Fourme T, Galié N, Ghofrani A, Harrison RE, Huez S, Humbert M, Janssen B, Kober J, Koehler R, Machado RD, Mereles D, Naeije R, Olschewski H, Provencher S, Reichenberger F, Retailleau K, Rocchi G, Simonneau G, Torbicki A, Trembath R, Seeger W. Stress-Doppler-echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxiaCirculation. 2009 Apr 7;119(13):1747-57

Bourbon JR, Boucherat O, Boczkowski J, Crestani B, Delacourt C. Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets. Trends Mol Med. 2009 Apr;15(4):169-79

Chemla D, Castelain V, Provencher S, Humbert M, Simonneau G, Hervé P. Evaluation of various empirical formulas for estimating mean pulmonary artery pressure by using systolic pulmonary artery pressure in adultsChest. 2009 Mar;135(3):760-768

Boucherat O, Guillou F, Aubin J, Jeannotte L. Hoxa5: a master gene with multifacted rolesMed Sci (Paris). 2009 Jan;25(1):77-82

2008

Ugalde P, Miro S, Provencher S, Quevillon M, Chau L, Deslauriers DR, Lacasse Y, Ferland S, Simard S, Ferland S, Deslauriers J. Ispsilateral diaphragmatic motion and lung function in long-term pneumonectomy patientsAnn Thorac Surg. 2008 Dec;86(6):1745-51; discussion 1751-2

Bonnet P,Awede B, Rochefort GY, Mirza A, Lermusiaux P, Domenech J, and Eder V. Electrophysiological maturation of rat mesenchymal stem cells after induction of vascular smooth muscle cell differentiation in vitroStem Cells Dev. 2008 Dec;17(6):1131-40

Hadchouel A, Decobert F, Franco-Montoya ML, Halphen I, Jarreau PH, Boucherat O, Martin E, Benachi A, Amselem S, Bourbon J, Danan C, Delacourt C. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung developmentPLoS One. 2008 Sep 11;3(9):e3188

Provencher S, Hervé P., Sitbon O, Humbert M, Simonneau G, Chemla D. Changes in Exercise hemodynamics during treatment in Pulmonary Arterial HypertensionEur Respir J. 2008 Aug;32(2):393-8

Moudgil R, Wu X, Bonnet S, Dyck JRB, Gallin W, Wieland B, Thebaud B, Michelakis ED, Archer SL. Identification of a structurally unique, human oxygen sensitive, voltage-gated potassium (HOSK) channel contained within the collagen 1 alpha gene.

Sawicka M, Dansereau A, Bonnet S, Bland R, Pierce R, Tremblay G, Bourbonnais Y, Eaton F, Wen L, Thébaud B. Protective Effect of Pre-elafin, a Natural Elastase Inhibitor, in Experimental Oxygen-induced Chronic Lung Injury in Newborn Rats.

Méhats C, Franco-Montoya ML, Boucherat O, Lopez E, Schmitz T, Zana E, Evain-Brion D, Bourbon J, Delacourt C, Jarreau PH. Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn ratsPLoS One. 2008;3(10):e3445

2007

Boucherat O, Franco-Montoya ML, Thibault C, Incitti R, Chailley-Heu B, Delacourt C, Bourbon JR. Gene expression profiling in lung fibroblasts reveals new players in alveolarization. Physiol Genomics. 2007 Dec 19;32(1):128-41

Koonen DP, Febbraio M, Bonnet S, Nagendran J, Young ME, Michelakis ED, Dyck JR. CD36 expression contributes to age-induced cardiomyopathy in miceCirculation. 2007 Nov 6;116(19):2139-47

Waszak P, Franqueville L, Franco-Motoya ML, Rosa-Calatrava M, Boucherat O, Lindholm L, Delacourt C, Boulanger P. Toxicity of fiber- and penton base-modified adenovirus type 5 vectors on lung development in newborn rats. Mol Ther. 2007 Nov;15(11):2008-16

McMurtry MS, Bonnet S, Michelakis ED, Bonnet S, Haromy A, Archer SL.. Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin (RATS) study. Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L933-40

Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED. The nuclear factor of activated T-cells in Pulmonary arterial hypertension can be therapeutically targetedProc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23

Bonnet S, Archer SL. Potassium Channel Diversity in the Pulmonary Arteries and Pulmonary Veins: Implications for regulation of the pulmonary vasculature in health and during pulmonary hypertensionPharmacol Ther. 2007 Jul;115(1):56-69

Boucherat O, Benachi A, Chailley-Heu B, Franco-Montoya ML, Elie C, Martinovic J, Bourbon JR. Surfactant maturation is not delayed in human fetuses with diaphragmatic hernia. PLoS MedPLoS Med. 2007 Jul 31;4(7):e237

Boucherat O, Bourbon JR, Barlier-Mur AM, Chailley-Heu B, D’Ortho MP, Delacourt C. Differential expression of matrix metalloproteinases and inhibitors in developing rat lung mesenchymal and epithelial cells. Pediatr Res. 2007 Jul;62(1):20-5

Boucherat O, Benachi A, Barlier-Mur AM, Franco-Montoya ML, Martinovic J, Thébaud B, Chailley-Heu B, Bourbon JR. Decreased lung fibroblast growth factor 18 and elastin in human congenital diaphragmatic hernia and animal modelsAm J Respir Crit Care Med. 2007 May 15;175(10):1066-77

Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED. A Mitochondria- Plasmamembrane K+ Channel Axis as a novel therapeutic target for cancerCancer Cell. 2007 Jan;11(1):37-51

2006

Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, Kawase Y, Jishage K, Lopaschuk GD. Malonyl CoA Decarboxylase Deletion in Mice Increases Cardiac Glucose Oxidation and Protects the Heart from Ischemic InjuryCirculation. 2006 Oct 17;114(16):1721-8

Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. An abnormal mitochondrial-HIF-1α-Kv channel pathway disrupts O2-sensing and triggers pulmonary arterial hypertension in fawn-hooded rats: similarities to human PAH. Circulation. 2006 Jun 6;113(22):2630-41

Lopez E, Boucherat O, Franco-Montoya ML, Bourbon JR, Delacourt C, Jarreau PH. Nitric oxide donor restores lung growth factor and receptor expression in hyperoxia-exposed rat pups. Am J Respir Cell Mol Biol. 2006 Jun;34(6):738-45

Provencher S, Sitbon O, Humbert M, Cabrol S, Jaïs X, Simonneau G. Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertensionEur Heart J. 2006 Mar;27(5):589-95

Provencher S, Herve P, Jais X, Lebrec D, Humbert M, Simonneau G, Sitbon O. Deleterious effects of beta-blockers on exercise capacity and hemodynamics in patients with portopulmonary hypertensionGastroenterology. 2006 Jan;130(1):120-6

Provencher S, Chemla D, Hervé P, Sitbon O, Humbert M, Simonneau G. Heart rate responses during the 6-minute walk test in pulmonary arterial hypertensionEur Respir J. 2006 Jan;27(1):114-20

Archer SL, Michelakis ED, Thébaud B, Bonnet S,Moudgil R, Wu XC, Weir EK. A central role for O2-sensitive K+ channels and mitochondria in the specialized O2-sensing system. 2005 Signaling pathways in acute oxygen sensingNovartis Found Symp. 2006;272:157-71; discussion 171-5, 214-7

2005

Ladha F, Bonnet S, Eaton F, Hashimoto K, Korbutt G, Thébaud B. Sildenafil Improves Alveolar Growth and Pulmonary Hypertension in Hyperoxia-Induced Lung InjuryAm J Respir Crit Care Med. 2005 Sep 15;172(6):750-6

Sitbon O, Humbert M, Jaïs X, Ioos V, Hamid AM, Provencher S, Garcia G, Parent F, Hervé P, Simonneau G. Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertensionCirculation. 2005 Jun 14;111(23):3105-11

Mc Murtry S, Archer SL,Bonnet S, Wu X, Haromy A and Michelakis E. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertensionJ Clin Invest. 2005 Jun;115(6):1479-91

Bourbon J, Boucherat O, Chailley-Heu B, Delacourt C. Control mechanisms of lung alveolar development and their disorders in bronchopulmonary dysplasia. Pediatr ResPediatr Res. 2005 May;57(5 Pt 2):38R-46R

Chailley-Heu B, Boucherat O, Barlier-Mur AM, Bourbon JR. FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in myofibroblatsAm J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L43-51

2003

Savineau JP,Bonnet S, Marthan R. Hypoxia-mediated regulation on Ca2+ transients in pulmonary artery smooth muscle cells. (In Hypoxic pulmonary vasoconstriction: cellular and molecular mechanisms) J YUAN, Editor Kluver Academic press 2003