Our team of research professional is a group of highly qualified personnel. The PAH research group is one of the largest employers of research professional at the Quebec Heart and Lung Institute (IUCPQ). This team offers our research group an impressive array of technological expertise ranging from molecular biology to animal surgeries.
The success of our group depends on the work of a team
of dedicated principal investigators, research coordinators and students.
Every day, each of them contributes to our success.
Sébastien Bonnet, PhD
Clinical research nurse
Clinical trials coordinator in pulmonary hypertension and oncology
I have been a nurse since 1993. From 1993 to 1997, I worked at Laval hospital on different wards (surgery, cardiology an internal medicine). Then, I left Québec city to work in Toronto at ‘Info health’. In 2002, I worked St-Hyacinthe hospital, in the intensive care unit before coming back to my home town wherer I worked at Chauveau Hospital for two years. I have been working at Laval hospital (IUCPQ) since 2004 as a clinical research nurse.
I am in charge of the coordination and planning of the clinical trials done in collaboration with pharmaceutical companies. I make sure the methodology of the protocols are carried out as intended while implementing the ethical review bord’s specifications are respected. I perform the techniques requested by the protocol and act as a link between the physician, the pharmaceutical company, and other people involved in the clinical trial.
Pascale Blais-Lecours, PhD
Clinical trial manager and research professional
After completing her laboratory technical training in biotechnologies at the Cégep de Lévis-Lauzon in 2007, Pascale continued her training at the university level with the DEC-BAC agreement of Laval University and completed her bachelor’s degree in Microbiology in 2009. She then joined Dr. Caroline Duchaine’s team, specializing in air microbiology at the research center of the Institut universitaire de cardiologie et de pneumologie de Québec, to carry out her graduate studies at the master’s and doctoral levels (2009 -2014) to assess the role of archaea in inflammation and their impact on human health. Pascale then worked as a research professional at CRIUCPQ in the team of Dr. David Marsolais, an expert in immunology and in the biology of sphingolipids (2014 to present). She was recently trained at the IUCPQ to manage the COZI clinical trial, initiated due to the COVID-19 pandemic and led, among others, by Dr. Marsolais, studying the efficacy and safety of ozanimod, a ligand for the sphingosine-1-phosphate receptor, in the treatment of COVID-19. These new tasks have enabled Pascale to acquire the knowledge necessary to become, in 2020, the manager of two clinical trials studying the efficacy and safety of apabetalone and olaparib in pulmonary hypertension, namely APPROACH and OPTION, directed by Dr. Steeve Provencher.
Programme d’Hypertension Pulmonaire
Cliniques spécialisées de pneumologie (CSP)
Clinique des maladies vasculaires et interstitielles pulmonaires
Alice Bourgeois, M. Sc.
As she was completing a bachelor’s degree in biology at Laval University, Alice first joined the pulmonary hypertension research group as a summer intern. During her B.Sc. in general biology, her interests quickly turned to cell biology and medical research. The internship with the team only confirmed and strengthened her interests about research in pathophysiology. She thus decided to continue her work and joined the research group to begin her master’s degree in January 2017. As her projects evolved, her curiosity and interest have prompted her to pursue her doctoral studies in order to deepen her knowledge in pathophysiology. Her main PhD project aims to understand the implication of epigenetic factors in pulmonary arterial hypertension and to identify new therapeutic targets. Thanks to the experience acquired in recent years, she also had the opportunity to occupy a position as a research professional in addition to her studies.
Sandra Breuils-Bonnet, M. Sc.
Professionnelle de recherche
Coordinatrice de la Bio-Banque
Titulaire d’une maitrise en Biologie Cellulaire et Physiologie, mon parcours professionnel m’a amené dans un laboratoire de chimie-biorganique en Italie, puis dans une plateforme d’analyse des défauts des vins à Bordeaux en France pour des analyses biochimiques par de nombreuses techniques de chromatographie et de spectrométrie de masse. Je travaille ensuite dans la recherche en Physiologie animale dans le groupe de recherche en Biologie Vasculaire à Edmonton en Alberta, puis de nouveau dans l’analyse de protéines et de biomarqueurs pour la plateforme protéomique du CHUL à Québec. Finalement Je reviens dans le domaine de la recherche au sein du groupe de recherche en hypertension pulmonaire en tant que coordinatrice de recherche clinique dans le but de gérer les analyses fondamentales à partir des échantillons issus de la recherche clinique.
Sandra Martineau, M. Sc.
Sandra did her undergraduate studies in biochemistry at Laval University. During those years, she did an internship in a laboratory at the research center of the Lung and Heart Institute specialized in chronic obstructive pulmonary disease (COPD). Thereafter, she completed a Master degree on the composition and function of the quadriceps in those patients. Since 2017, she’s been working in the pulmonary hypertension group as a research assistant.
Ghada Mkannez, Ph.D.
Ghada obtained her PhD degree in Immunology in 2015 at the Pasteur Institute in Tunis, Tunisia. Her research project focused on the modulation of immune response in human macrophages infected with the Leishmania parasite. She then joined the Institute of Cardiology and Pneumology of Quebec (IUCPQ) for a postdoctoral fellowship within Dr. Patrick Mathieu’s research group (2015-2018) where she focused her research on the epigenetic regulation of differently expressed genes in the aortic valve of patients with aortic stenosis. She then joined the CHU de Quebec Research Center, to work as a research professional within Dr. Manu Rangachari’s research group (2019-2020). In collaboration with a pharmaceutical company, her research project focused on a preclinical study on an animal model of multiple sclerosis. Recently, she joined the pulmonary hypertension research group where she will use her expertise to develop new molecular biology techniques and contribute to the advancement of various research projects.
Valérie Nadeau, Ph. D.
Valérie completed her bachelor’s degree in Biology at Laval University in 2005. During her undergraduate studies, she had the opportunity to work in a laboratory as an intern at the cancer research center at Hôtel-Dieu de Québec (CRHDQ). This introduction to laboratory research convinced her that she wanted to continue her studies in order to deepen her knowledge. She completed her Master’s and PhD in Cellular and Molecular Biology at CRHDQ. Her research project focused on the characterization of the role of the ERK/MAPK cell signalling pathway in lung organogenesis and during embryonic development, more specifically in angiogenic processes that occur during placental-blood barrier development. Since 2014, she has been a research professional in the Pulmonary Arterial Hypertension (PAH) group. She uses her knowledge and expertise to contribute to the advancement of the projects conducted by the group by specializing in, among others, the field of histology, anatomy, and microscopy.
Mark earned a Master of Science degree in Biological Sciences from Dominican University of California. With continued interest in the inquisitive and interesting nature of basic research, he sought to remain in the academic space and took a position as the lab manager of a start-up lab at Stanford University. Seven years after the successful launch and growth of the de Jesus Perez lab at Stanford, Mark decided to join the Bonnet/Provencher lab in Québec, Canada, taking advantage of the opportunity to travel and live in another part of the world while still working on a career as a lab technician and administrator. Mark is responsible for cell culture operations and protocol development in the Bonnet/Provencher lab.
Kana Shimauchi graduated from the School of Nursing at Chiba University in Japan in 2007. She worked as a clinical nurse in Japan until she started her career as a research assistant in the Pulmonary Hypertension Research Group in 2020.
Ève Tremblay, B. Sc.
After completing her bachelor’s degree in medical biology at UQTR in 2008, Eve continued her master’s training in Physiology-Endocrinology at CHUL research center. Her work focused on the involvement of immune cells as well as vascular remodeling in glioblastomas. She then joined Dr Bonnet’s team in 2011, before the creation of the Pulmonary Arterial Hypertension research group. Her expertise in laboratory work and management is put to good use within the group. Eve is responsible for all projects involving animals by writing the ethical protocols, training students and performing vascular surgeries on rodents.