The PAH research group offers an extraordinary and rewarding training environment thanks to its highly knowledgeable professors and highly qualified staff. Our group is internationally recognized for its translational research work.
Students are the vectors that allow fundamental research to evolve into clinical trials. Carrying out graduate and postgraduate studies in the PAH research group allows our students to leave an imprint on the history of the understanding and treatment of vascular disease. Many of our students have won prestigious national and international awards, published in the best scientific journals in the field, and have a bright future.
Post doctoral's degree
The success of our group depends on the work of a team
of dedicated principal investigators, research coordinators and students.
Every day, each of them contributes to our success.
Sébastien Bonnet, PhD
Yankin Niu, Ph.D.
Yukimitsu Kuwabara, M.D., Ph.D.
After obtaining his medical degree at Kyushu University in 2009, Yukimitsu started his career in 2011 as a cardiovascular physician in Fukuoka at Kyushu University hospital, Japan.
In a meanwhile, he learned basic research in Graduate School of Kyushu University, Japan. He obtained his Ph.D. in 2019 with his research about the role of thrombin receptor (PAR1) in pulmonary hypertension. He is also a certified member of the Japanese Circulation Society.
In May 2023 Yukimitsu joined the Pulmonary Hypertension Research Group at the CRIUCPQ as a postdoctoral fellow to investigate the mechanism of right ventricular failure in pulmonary hypertension.
Manon Mougin, Bac.
Coming from Belfort city in France, Manon quickly became very interested in the fields of Sciences. She passed her scientific diploma of College studies in 2018 before following two years of medicine where she discovered the world of Biology research. She then continued her career with a bachelor degree in molecular biology, biochemistry and human physiology at the University of Besançon (France) which she obtained in 2022. In September 2022 she joined the team of Drs Bonnet and Boucherat for a master’s degree in molecular medicine at Laval University. She is currently working on the role of a protein called Aurora-Kinase in hypertension.
Antonella Abi Sleimen, M.Sc.
Reem El Kabbout, M.Sc.
Reem, the enthusiastic biologist, has graduated from the Lebanese University with a BSc degree in Biology, a Master 1 degree in Molecular Biology and a Master 2 degree in Biotechnology. She has a strong background in bioinformatics and an extensive experience working with statistical analysis tools, namely R, and she is also highly skilled at analyzing the NGS and RNA seq data in the Linux system. During her Master 2 internship in collaboration with the Biomolecules engineering laboratory in Nancy, France, she developed and improved her skills in metagenomics, metabarcoding, and bioinformatics. Her intellectual curiosity, her passion and her interests in being an effective member in research area led her to decide to pursue her PhD in biomedical sciences in Quebec City. Currently, she is working on her PhD project under the supervision of Dr. François Potus. Her project mainly involves the study of the effects of the DNA methylation, an epigenetic mechanism, on the Pulmonary Arterial Hypertension. She is also working on several bioinformatics and RNA-seq projects for the group.
Keiko Yamamoto, M.D., Ph. D.
Keiko Yamamoto completed her Respiratory Internship after obtaining her medical degree in 2011 at Keikyo University, Tokyo in Japan. In 2014, she entered Chiba University to do basic and clinical research on pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, which earned her her PhD degree in 2019. In 2020, Keiko Yamamoto joined the Quebec Pulmonary Hypertension Research Group to continue her research in hypertension.
Alice Bourgeois, M. Sc.
As she was completing a bachelor’s degree in biology at Laval University, Alice first joined the pulmonary hypertension research group as a summer intern. During her B.Sc. in general biology, her interests quickly turned to cell biology and medical research. The internship with the team only confirmed and strengthened her interests about research in pathophysiology. She thus decided to continue her work and joined the research group to begin her master’s degree in January 2017. As her projects evolved, her curiosity and interest have prompted her to pursue her doctoral studies in order to deepen her knowledge in pathophysiology. Her main PhD project aims to understand the implication of epigenetic factors in pulmonary arterial hypertension and to identify new therapeutic targets. Thanks to the experience acquired in recent years, she also had the opportunity to occupy a position as a research professional in addition to her studies.
Charles-Antoine Guay, M.D., M. Sc.
Doctoral student in clinical epidemiology - with thesis,
Medical student, Laval University
Dr. Guay is a medical resident in public health and preventive medicine at the University of Sherbrooke and a PhD candidate in epidemiology at Laval University where, in 2015, Charles joined the Pulmonary Hypertension Research Group. In combination with his medicine studies, he first achieved a master’s degree in clinical epidemiology for which he obtained a leadership and sustainable development scholarship from Laval University in 2016. He then embarked on a doctorate in epidemiology while starting his medical training specializing in public health and preventive medicine in 2019. Ultimately, his goal is to learn and flourish within the research group and become a better doctor in support of his community.
Charlotte Romanet, M. Sc.
Victoria Toro, M. Sc.
Victoria graduated with a master’s in Physiology specializing in cardiovascular, metabolic and nutritional regulations in clinical and fundamental research. Her internship at CRNH Rhône Alpes in France focused on the pathology of obesity allowed her to observe and learn the complex and robust nature of clinical research. Between her internship at an HP2 Grenoble laboratory in France studying vascular smooth muscle cell function in normoxia or intermittent hypoxia and at CRIUCPQ studying the interactions between ovarian hormones and corticosterone on cardio-respiratory control, she developed a pronounced taste for fundamental medical research as it aroused her curiosity. She thus decided to pursue a doctorate under the theme of pulmonary arterial hypertension (PAH). She joined the team of Dr. Bonnet and Dr. Provencher in October 2019 to start her doctorate in clinical and biomedical sciences with an original project studying the impact of breast cancer on the penetrance of PAH in individuals with BMPR2 mutations. Looking forward, she plans to embark on a new project focused on the heart in PAH with Dr. Potus.
Native of Montpellier city, France, Yann obtained a bachelor’s degree in health biology before specializing in microbiology and immunology for his master’s degree at the University of Montpellier II. During an internship at the French National Research Institute for Sustainable Development on the genetic diversity of HIV (IRD), he developed a particular interest in translational research, specifically in the physiology of the cardiovascular and respiratory systems. Pulmonary arterial hypertension (PAH) being one of the complications of an HIV infection, he enthusiastically joined in 2019 the PAH group of Quebec led by Professors Sébastien Bonnet and Steeve Provencher in order to carry out a Ph.D. under the supervision of Dr Bonnet. After studying first the involvement of the FOXO3 transcription factor in the development of PAH, his current interests for cardiac physiology growing, he is actually working on coronary vascular remodelling.
Annie Christine Lajoie, M.D.
Respirology and Research Fellow – Sleep breathing disorders, McGill University
Master student – Clinical epidemiology program, Laval University
After obtaining her respirology certification, Dr. Lajoie pursued her training in research focusing on sleep-disordered breathing at McGill University. She is simultaneously completing a master’s degree in clinical epidemiology at Université Laval under the supervision of Dr. Steeve Provencher.
Her research interests include sleep breathing disorders, namely obstructive sleep apnea and pulmonary vascular diseases as well as the interaction between these two entities. She is the recipient of a research award from the Canadian Society for Clinical Investigation (2019), underlining her research work conducted during her years as a medical resident. More recently, she was awarded the prestigious McLaughlin Scholarship (Laval University 2019 and 2020).
Her work is financially supported by the American Thoracic Society ASPIRE fellowship (2020-2021). After the completion of her research fellowship, Dr. Lajoie has join the IUCPQ’s respirology team in the fall of 2021.
Sarah-Éve joined the pulmonary research group for two internships in the fall of 2019 and the summer of 2020, and obtained her Bachelor’s degree in Pharmacology from the University of Sherbrooke. This induction into research confirmed her interests in human physiology and medical research, motivating her to pursue her university degree at the master’s level. She has enthusiastically begun her master’s degree in January 2021 in Clinical and Biomedical Sciences in the group under the supervision of Drs Sébastien Bonnet & Dr Olivier Boucherat, during which she completed her Master’s degree in just 1 year. As of May 2022, Sarah-Eve has been pursuing her Doctoral studies and she will deepen her numerous knowledges in pulmonary arterial hypertension research with passion and dedication. Her research project aims at investigating the role of hypusine and integrins signalling pathways in PAH.
Simon Lemieux, M.D,
Master student in Clinical Epidemiology, Laval University
Resident in Diagnostic Radiology, Laval University
While completing his residency in diagnostic radiology, Simon enrolled in a master’s program in Clinical Epidemiology in 2017. His research interest is the evaluation of interventional radiology procedures in thoracic and abdominal radiology, inspired by the clinical applications of novel technologies in radiology. Notably, Simon has started a project that aims to evaluate the utility and possibilities of artificial intelligence in the creation of magnetic resonance images from computed tomography native images. Simon is a laureate of the Réginald-Langelier award (2019-2020) for his oral presentation at the RSNA 2019 Annual Meeting in Chicago, Illinois. After a fellowship year at Stanford University in Body Imaging, Simon will join the team of radiologists at Saint-François-d’Assise Hospital.