{"id":16335,"date":"2020-04-06T12:35:04","date_gmt":"2020-04-06T16:35:04","guid":{"rendered":"https:\/\/phrg.ca\/le-groupe\/collaborateurs-nationaux-internationaux\/"},"modified":"2025-04-29T15:37:46","modified_gmt":"2025-04-29T19:37:46","slug":"collaborateurs-nationaux-internationaux","status":"publish","type":"page","link":"https:\/\/phrg.ca\/en\/le-groupe\/collaborateurs-nationaux-internationaux\/","title":{"rendered":"National and international collaborators"},"content":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1584807143299{margin-bottom: 40px !important;}&#8221;][vc_column][vc_column_text]<span class=\"goog-text-highlight\">The PAH research group has an established reputation which has made it possible to build a network of collaborators, bringing together the best national and international researchers in pulmonary vascular disease. <\/span>This international recognition enables members of the PAH research group to occupy leading decision-making positions in major international scientific associations such as the American Heart Association (AHA), the American Thoracic Society (ATS), the World Symposia on Pulmonary Hypertension (WSPH) association, the Pulmonary Vascular Research Institute (PVRI), the European Respiratory Society (ERS) and the European Society of Cardiology (ESC).[\/vc_column_text][vc_empty_space height=&#8221;30px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/6&#8243;]<div id='ins-image-box69d7dfa67ee77' class='ins-image-box-wrapper ins-image-box-style-1 text-center   ' ><div class='ins-image-box-inner'><div class='ins-image-box-img text-center'><a class='ins-image-box-img-link' href='#rowRK' target='_self'><img src='https:\/\/phrg.ca\/wp-content\/uploads\/2025\/04\/Rajkumar-Savai-2-copy-e1745943011641.jpg' alt='image-box'><\/a><\/div><div class='ins-image-content-wrapper last-paragraph-no-margin'><div class='ins-image-box-content-inner'><div class='ins-image-box-title margin-10px-bottom'><h6 class='ins-image-box-title-inner letter-spacing-05 title-font font-weight-500 display-block margin-0px-bottom  text-extra-large default'><span class='ins-image-box-number'><\/span> Rajkumar Savai<\/h6><\/div><p class='ins-image-box-text '>PhD,<br \/>\n\ud83c\udde9\ud83c\uddea<\/p><\/div><\/div><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;]<div id='ins-image-box69d7dfa67f245' class='ins-image-box-wrapper ins-image-box-style-1 text-center   ' ><div class='ins-image-box-inner'><div class='ins-image-box-img text-center'><a class='ins-image-box-img-link' href='#rowFP' target='_self'><img src='https:\/\/phrg.ca\/wp-content\/uploads\/2023\/10\/Soni-S-Pullamsetti-1.png' alt='image-box'><\/a><\/div><div class='ins-image-content-wrapper last-paragraph-no-margin'><div class='ins-image-box-content-inner'><div class='ins-image-box-title margin-10px-bottom'><h6 class='ins-image-box-title-inner letter-spacing-05 title-font font-weight-500 display-block margin-0px-bottom  text-extra-large default'><span class='ins-image-box-number'><\/span> Soni Savai Pullamsetti<\/h6><\/div><p class='ins-image-box-text '>PhD<br \/>\n\ud83c\udde9\ud83c\uddea<\/p><\/div><\/div><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;]<div id='ins-image-box69d7dfa67f790' class='ins-image-box-wrapper ins-image-box-style-1 text-center   ' ><div class='ins-image-box-inner'><div class='ins-image-box-img text-center'><a class='ins-image-box-img-link' href='#rowEM' target='_self'><img src='https:\/\/phrg.ca\/wp-content\/uploads\/2020\/04\/Michelakis-Evangelos.jpg' alt='image-box'><\/a><\/div><div class='ins-image-content-wrapper last-paragraph-no-margin'><div class='ins-image-box-content-inner'><div class='ins-image-box-title margin-10px-bottom'><h6 class='ins-image-box-title-inner letter-spacing-05 title-font font-weight-500 display-block margin-0px-bottom  text-extra-large default'><span class='ins-image-box-number'><\/span> Evangelos Michelakis<\/h6><\/div><p class='ins-image-box-text '>MD, PhD<br \/>\n\ud83c\udde8\ud83c\udde6<\/p><\/div><\/div><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;]<div id='ins-image-box69d7dfa67fb36' class='ins-image-box-wrapper ins-image-box-style-1 text-center   ' ><div class='ins-image-box-inner'><div class='ins-image-box-img text-center'><a class='ins-image-box-img-link' href='#rowMH' target='_self'><img src='https:\/\/phrg.ca\/wp-content\/uploads\/2023\/10\/Pr-marc-humbert2-2.png' alt='image-box'><\/a><\/div><div class='ins-image-content-wrapper last-paragraph-no-margin'><div class='ins-image-box-content-inner'><div class='ins-image-box-title margin-10px-bottom'><h6 class='ins-image-box-title-inner letter-spacing-05 title-font font-weight-500 display-block margin-0px-bottom  text-extra-large default'><span class='ins-image-box-number'><\/span> Marc Humbert<\/h6><\/div><p class='ins-image-box-text '>MD, PhD<br \/>\n\ud83c\uddeb\ud83c\uddf7<\/p><\/div><\/div><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column]<div id='ins-heading-69d7dfa67fee2' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '><\/h3><h6 class='section-heading-subtitle title-font  default '>Other collaborators<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<ul>\n<li>Stephen L. Archer (Queen&#8217;s University, Kingston, Ontario \ud83c\udde8\ud83c\udde6)<\/li>\n<li>Harm Jan Bogaard (Amsterdam UMC, Amsterdam, Netherlands \ud83c\uddf3\ud83c\uddf1)<\/li>\n<li>Stephen Y. Chan (University of Pittsburgh, US \ud83c\uddfa\ud83c\uddf8)<\/li>\n<li>Vinicio de Jesus Perez\u00a0 (Stanford University, US \ud83c\uddfa\ud83c\uddf8)<\/li>\n<li>Marie-Jos\u00e9e Goumans (University of Leiden, Netherlands \ud83c\uddf3\ud83c\uddf1)<\/li>\n<li>John Granton (Toronto General Hospital, Toronto, Ontario \ud83c\udde8\ud83c\udde6)<\/li>\n<li>Tim Lahm (University of Colorado, Denver, US \ud83c\uddfa\ud83c\uddf8)<\/li>\n<li>David Langleben (McGill University, Montr\u00e9al, Qu\u00e9bec \ud83c\udde8\ud83c\udde6)<\/li>\n<li>Sanjay Mehta (Lawson Health Sciences Centre, London, Ontario \ud83c\udde8\ud83c\udde6)<\/li>\n<li>Lisa Mielniczuk (University of Ottawa, Ontario \ud83c\udde8\ud83c\udde6)<\/li>\n<li>Nick Morrell (University of Cambridge, UK \ud83c\uddec\ud83c\udde7)<\/li>\n<li>Ralph T Schermuly (University of Giessen, Bad Nauheim, Germany \ud83c\udde9\ud83c\uddea)<\/li>\n<li>Kurt Stenmark (University of Colorado, Denver, US \ud83c\uddfa\ud83c\uddf8)<\/li>\n<li>Mark Toshner (University of Cambridge, UK \ud83c\uddec\ud83c\udde7)<\/li>\n<li>Jason Weatherald MD (University of Alberta, Edmonton, Alberta \ud83c\udde8\ud83c\udde6)<\/li>\n<li>Junichi Omura (Janssen, Japan \ud83c\uddef\ud83c\uddf5)<\/li>\n<li>Tsukasa Shimauchi (St. Mary&#8217;s Hospital, Kurume, Fukuoka, Japan \ud83c\uddef\ud83c\uddf5)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; content_placement=&#8221;middle&#8221; color_scheme=&#8221;white&#8221; css=&#8221;.vc_custom_1604060318653{margin-top: 40px !important;background-image: url(https:\/\/phrg.ca\/wp-content\/uploads\/2020\/10\/iStock-1173329540-m1.png?id=16221) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/12&#8243;][\/vc_column][vc_column width=&#8221;10\/12&#8243;][vc_column_text css=&#8221;.vc_custom_1604152640921{margin-top: 20px !important;margin-bottom: 50px !important;}&#8221;]<\/p>\n<h4 style=\"text-align: center;\"><em><span class=\"goog-text-highlight\">The success of our group depends on the work of a team<br \/>\nof dedicated principal investigators, research coordinators and students.<br \/>\nEvery day, each of them contributes to our success.<\/span><\/em><\/h4>\n<p style=\"text-align: center;\">S\u00e9bastien Bonnet, PhD<\/p>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/12&#8243;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1586198056977{margin-bottom: 20px !important;}&#8221; el_id=&#8221;rowMH&#8221;][vc_column][vc_empty_space height=&#8221;80px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;17312&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;]<div id='ins-heading-69d7dfa67ff07' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Marc Humbert, MD, PhD<\/h3><h6 class='section-heading-subtitle title-font  default '>Director of the Pulmonary Hypertension Physiopathology and Therapeutic Innovation Laboratory, INSERM U999, Universit\u00e9 Paris-Saclay, France<br \/>\nDean of the Paris-Saclay Faculty of Medicine<br \/>\nHead of the Pneumology and Intensive Respiratory Care department at the AP-HP Bic\u00eatre hospital, Paris<br \/>\nFormer President of the European Respiratory Society<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<p class=\"bodytext\">President of the European Respiratory Society, Marc Humbert is Professor of Respiratory Medicine, Vice Dean for Research and Director of the Inserm Unit 999 at Universit\u00e9 Paris-Saclay, France. He is the Director of the Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension Reference Centre H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris, France. Marc Humbert was the Chief Editor of the European Respiratory Journal from 2013 to 2017 and he is currently Section Editor for Pulmonary Vascular Medicine. He has received many distinctions. Since 2017, Marc Humbert is the vice-coordinator of the European Reference Network for rare and low prevalence respiratory diseases (ERN-LUNG). In 2018, Clarivate Analytics has listed Pr Marc Humbert as one of the world&#8217;s highly cited researchers in the field of Clinical Medicine.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1586262942997{margin-bottom: 20px !important;}&#8221; el_id=&#8221;rowEM&#8221;][vc_column][vc_empty_space height=&#8221;80px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;15531&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;]<div id='ins-heading-69d7dfa67ff2f' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Evangelos Michelakis MD, PhD<\/h3><h6 class='section-heading-subtitle title-font  default '>Director, Pulmonary Hypertension Program<br \/>\nCanada Research Chair in Molecular and Mitochondrial Medicine<br \/>\nVice Chair \u2013 Research, Department of Medicine, University of Alberta, Edmonton<br \/>\nDirector, Faculty of Medicine &amp; Dentistry - Cardiovascular Research Institute<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<p class=\"bodytext\"><strong data-start=\"52\" data-end=\"76\">Evangelos Michelakis<\/strong> was born in Greece, where he attended medical school at the University of Patras. He completed training in vascular biology, internal medicine, and cardiology at the University of Texas (Galveston), Yale University, and the University of Minnesota. He joined the faculty at the University of Alberta in 1998 and has since achieved the rank of professor. He is currently the Vice Chair (Research) in the Department of Medicine.<\/p>\n<p>[\/vc_column_text]<div class=\"ins-toggle ins_toggle69d7dfa67ff6c  \" data-uid=\"ins_toggle69d7dfa67ff6c\"><div class=\"\"><div class=\"toggle_inner_wrap\"><div class=\"ins_toggle69d7dfa67ff6c ins-toggle-click \"><div id='ins-button-69d7dfa67ff6d' class='ins-button-wrapper text-left 0px 0px  vc_custom_1745946274708 ' ><div class='ins_toggle_button'><a class='ins-button toggle-button text-white pc-border pc-bg btn-radius-default default btn-small  '><span>See more<\/span><\/a><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {jQuery(\"head\").append(\"<style>#ins-button-69d7dfa67ff6d.ins-button-wrapper {margin-top: 0px;}#ins-button-69d7dfa67ff6d.ins-button-wrapper {margin-bottom: 0px;}<\/style>\")\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script><\/div><\/div><div id=\"ins_toggle69d7dfa67ff6c\" class=\"toggle-class\"  style=\"display:none;\" >[vc_column_text]<\/p>\n<p class=\"\" data-start=\"52\" data-end=\"176\">He founded and has been directing the <strong data-start=\"90\" data-end=\"135\">Pulmonary Hypertension Clinic and Program<\/strong> at the University of Alberta since 2001.<\/p>\n<p class=\"\" data-start=\"178\" data-end=\"566\">Dr. Michelakis is also a <strong data-start=\"203\" data-end=\"225\">vascular biologist<\/strong> and leads a dynamic laboratory focused on discovering new treatments for <strong data-start=\"299\" data-end=\"340\">pulmonary arterial hypertension (PAH)<\/strong>. His group was the first to report, through two small independent clinical trials not funded by industry, the benefits of <strong data-start=\"463\" data-end=\"486\">Viagra (sildenafil)<\/strong> in PAH; this finding led to the global approval of the drug for this condition.<\/p>\n<p class=\"\" data-start=\"568\" data-end=\"912\">He is the <strong data-start=\"578\" data-end=\"660\">President-Elect of Council 3 \u2013 Circulation, Pulmonary, and Resuscitation (CPR)<\/strong> of the American Heart Association and serves on the editorial boards of <em data-start=\"733\" data-end=\"746\">Circulation<\/em>, <em data-start=\"748\" data-end=\"770\">Circulation Research<\/em>, <em data-start=\"772\" data-end=\"811\">American Journal of Physiology \u2013 Lung<\/em>, among others. He holds a <strong data-start=\"838\" data-end=\"911\">Canada Research Chair in Applied Molecular and Mitochondrial Medicine<\/strong>.<\/p>\n<p class=\"\" data-start=\"914\" data-end=\"1120\">Recently, he discovered intriguing similarities between <strong data-start=\"970\" data-end=\"1032\">mitochondrial biology in pulmonary hypertension and cancer<\/strong>, which has led him to build an exciting <strong data-start=\"1073\" data-end=\"1119\">translational research program in oncology<\/strong>.<\/p>\n<p class=\"\" data-start=\"1122\" data-end=\"1477\">His work has been published in journals such as <em data-start=\"1170\" data-end=\"1202\">Science Translational Medicine<\/em>, <em data-start=\"1204\" data-end=\"1217\">Circulation<\/em>, <em data-start=\"1219\" data-end=\"1241\">Circulation Research<\/em>, <em data-start=\"1243\" data-end=\"1284\">Journal of Clinical Investigation (JCI)<\/em>, <em data-start=\"1286\" data-end=\"1342\">Proceedings of the National Academy of Sciences (PNAS)<\/em>, among others, and has been featured in mainstream media including <em data-start=\"1410\" data-end=\"1430\">The New York Times<\/em>, <em data-start=\"1432\" data-end=\"1447\">The Economist<\/em>, <em data-start=\"1449\" data-end=\"1459\">Newsweek<\/em>, <em data-start=\"1461\" data-end=\"1466\">CNN<\/em>, and more.<\/p>\n<p>[\/vc_column_text]<\/div><\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1603805133554{margin-bottom: 20px !important;}&#8221; el_id=&#8221;rowFP&#8221;][vc_column][vc_empty_space height=&#8221;80px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;17293&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;]<div id='ins-heading-69d7dfa67ff9e' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Soni Savai Pullamsetti, PhD<\/h3><h6 class='section-heading-subtitle title-font  default '>Professor, Internal medicine, Justus Liebig University Giessen, Germany<br \/>\nPrinciple investigator at the Max Plank Institute for Heart &amp; Lung Research in the Department of Lung Development and Remodeling<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<p class=\"\" data-start=\"65\" data-end=\"573\"><strong data-start=\"65\" data-end=\"101\">Prof. Dr. Soni Savai Pullamsetti<\/strong> is a principal investigator at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany, and a professor at Justus Liebig University Giessen. With academic roots in India, she completed her PhD and postdoctoral studies in Germany before assuming her current research leadership role in 2011. She is actively involved in major research networks such as ECCPS II, ATS, DZL, and UGMLC, and serves on the editorial boards of <em data-start=\"543\" data-end=\"563\">Scientific Reports<\/em> and PVRI.<\/p>\n<p class=\"\" data-start=\"575\" data-end=\"1160\">Her research focuses on uncovering the molecular mechanisms behind <strong data-start=\"642\" data-end=\"673\">Pulmonary Hypertension (PH)<\/strong> and <strong data-start=\"678\" data-end=\"700\">Pulmonary Fibrosis<\/strong>, aiming to develop innovative therapies. In PH, her team studies signaling pathways (e.g., tyrosine kinases, phosphodiesterases), transcription factors (FoxO, Beta-catenin, HIF), and epigenetic factors (HDACs, Jumonji proteins), addressing vascular remodeling and right heart dysfunction. In Pulmonary Fibrosis, she investigates similar molecular targets to understand tissue remodeling and scar formation, particularly in Idiopathic Pulmonary Fibrosis (IPF).<\/p>\n<p class=\"\" data-start=\"1162\" data-end=\"1315\">Her work bridges basic research and clinical application, contributing significantly to the development of targeted treatments for chronic lung diseases.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1745943863417{margin-bottom: 20px !important;}&#8221; el_id=&#8221;rowRK&#8221;][vc_column][vc_empty_space height=&#8221;80px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;17494&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;]<div id='ins-heading-69d7dfa67ffbc' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Rajkumar Savai, PhD<\/h3><h6 class='section-heading-subtitle title-font  default '>Professor, Internal medicine, Justus Liebig University Giessen, Germany<br \/>\nPrinciple investigator at the Max Plank Institute for Heart &amp; Lung Research in the Department of Lung Development and Remodeling<br \/>\nHead of the Oncology Basic Research Unit at Medical Clinic V of the University Hospital of Giessen and Marburg in Giessen<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<p class=\"\" data-start=\"65\" data-end=\"486\"><strong data-start=\"65\" data-end=\"93\">Prof. Dr. Rajkumar Savai<\/strong> is a professor at the Institute for Lung Health (ILH) at Justus Liebig University in Giessen, Germany, where he leads the research group on the &#8220;Lung Microenvironmental Niche in Cancerogenesis.&#8221; He also heads the Oncology Basic Research Unit at the University Hospital of Giessen and Marburg and serves as a group leader at the Max Planck Institute for Heart and Lung Research in Bad Nauheim.<\/p>\n<p class=\"\" data-start=\"488\" data-end=\"805\">Originally from Warangal, India, Dr. Savai earned his MSc in Biochemistry before moving to Germany for his PhD and postdoctoral research. Since 2010, he has led independent research and, in 2020, was appointed to a professorship supported by the prestigious Heisenberg Program of the German Research Foundation (DFG).<\/p>\n<p class=\"\" data-start=\"807\" data-end=\"1214\">He plays key roles in several national and international research initiatives, including the German Center for Lung Research (DZL), the American Thoracic Society (ATS), the Network Genomic Medicine (nNGM) Lung Cancer, the LOEWE iCANx consortium, and is a faculty member at both the Cardio-Pulmonary Institute (CPI) and Frankfurt Cancer Institute (FCI). He has also served as a visiting professor in the U.S.<\/p>\n<p class=\"\" data-start=\"1216\" data-end=\"1556\">Prof. Savai has received numerous awards for his work and has published over 85 articles in high-impact journals such as <em data-start=\"1337\" data-end=\"1354\">Nature Medicine<\/em>, <em data-start=\"1356\" data-end=\"1388\">Science Translational Medicine<\/em>, <em data-start=\"1390\" data-end=\"1408\">Science Advances<\/em>, and <em data-start=\"1414\" data-end=\"1431\">Cancer Research<\/em>. His research focuses on the interaction between tumors and the lung microenvironment in cancer development and progression.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row disable_element=&#8221;yes&#8221; css=&#8221;.vc_custom_1600350406623{margin-bottom: 20px !important;}&#8221; el_id=&#8221;rowPB&#8221;][vc_column][vc_empty_space height=&#8221;80px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;15527&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;]<div id='ins-heading-69d7dfa67ffdc' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Pierre Bonnet<\/h3><h6 class='section-heading-subtitle title-font  default '>Professeur d\u2019Education Physique et sportive,<br \/>\nCardiologue, Pneumologue,<br \/>\nProfesseur des Universit\u00e9s-Praticien Hospitalier, CHU de Tours<br \/>\nCollaborateur international<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<p class=\"bodytext\">J\u2019occupe un poste de Professeur des Universit\u00e9s-Praticien Hospitalier \u00a0au CHU de Tours\u00a0: Pole C\u0153ur Thorax vaisseau h\u00e9mostase\u00a0; Cardiologie B H\u00f4pital Trousseau &#8211; Avenue de la R\u00e9publique \u00e0 Chambray l\u00e8s-Tours Fran\u00e7e.<\/p>\n<p class=\"bodytext\"><b>Recherche<\/b><br \/>\nJ\u2019ai cr\u00e9\u00e9 et dirig\u00e9 une \u00e9quipe de recherche sur la Physiopathologie de la paroi art\u00e9rielle. Mon axe de recherche sur la vasoconstriction hypoxique de l\u2019art\u00e8re pulmonaire a permis de d\u00e9montrer l\u2019implication des canaux potassiques des cellules musculaires lisses d\u2019art\u00e8re pulmonaire de rat et leur r\u00e9gulation par le monoxyde de carbone. Sur un mod\u00e8le de rat hypoxique chronique j\u2019ai montr\u00e9 l\u2019acc\u00e9l\u00e9ration du flux sanguin pulmonaire par \u00e9chocardiographie. Plus r\u00e9cemment j\u2019ai \u00e9tudi\u00e9 le r\u00f4le des cellules souches dans le remodelage de la paroi art\u00e9rielle.<\/p>\n<p class=\"bodytext\">Je collabore avec le Groupe hypertension pulmonaire de Qu\u00e9bec notamment sur les processus de remodelage vasculaire et l\u2019intol\u00e9rance \u00e0 effort.<\/p>\n<p>[\/vc_column_text]<div class=\"ins-toggle ins_toggle69d7dfa680000  \" data-uid=\"ins_toggle69d7dfa680000\"><div class=\"\"><div class=\"toggle_inner_wrap\"><div class=\"ins_toggle69d7dfa680000 ins-toggle-click \"><div id='ins-button-69d7dfa680001' class='ins-button-wrapper text-left 0px 0px  vc_custom_1586181714717 ' ><div class='ins_toggle_button'><a class='ins-button toggle-button text-white pc-border pc-bg btn-radius-default default btn-small  '><span>Voir plus<\/span><\/a><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {jQuery(\"head\").append(\"<style>#ins-button-69d7dfa680001.ins-button-wrapper {margin-top: 0px;}#ins-button-69d7dfa680001.ins-button-wrapper {margin-bottom: 0px;}<\/style>\")\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script><\/div><\/div><div id=\"ins_toggle69d7dfa680000\" class=\"toggle-class\"  style=\"display:none;\" >[vc_column_text]<\/p>\n<p class=\"bodytext\"><b>Enseignement<br \/>\n<\/b>J\u2019enseigne la physiologie cardiaque et vasculaire et la m\u00e9decine du sport aux \u00e9tudiants de la Facult\u00e9 de m\u00e9decine de Tours.<\/p>\n<p class=\"bodytext\"><b>Clinique<\/b><br \/>\nJ\u2019assure une consultation de Cardiologie et de M\u00e9decine du sport et je r\u00e9alise les \u00e9chographies cardiaques des patients de Pneumologie et de M\u00e9decine interne en particulier ceux atteints\u00a0 d\u2019hypertension art\u00e9rielle pulmonaire.<\/p>\n<p class=\"bodytext\"><b>Publications<br \/>\n<\/b><a class=\"internal-link\" href=\"http:\/\/www.hypertensionarteriellepulmonaire.ca\/index.php?id=1077&amp;L=0\">Cliquez ici pour voir les publications du Dr Pierre Bonnet \u00a0<\/a><\/p>\n<p>[\/vc_column_text]<\/div><\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row disable_element=&#8221;yes&#8221; css=&#8221;.vc_custom_1600350422262{margin-bottom: 20px !important;}&#8221; el_id=&#8221;rowCP&#8221;][vc_column][vc_empty_space height=&#8221;80px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;15533&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;]<div id='ins-heading-69d7dfa680026' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Christophe Pison M.D., Ph. D.<\/h3><h6 class='section-heading-subtitle title-font  default '>Pneumologue<br \/>\nUniversit\u00e9 de Grenoble<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text]<\/p>\n<p class=\"bodytext\">Le Pr. Christophe Pison est Pneumologue, Praticien Hospitalier, Chef de la Clinique Universitaire de Pneumologie au sein du CHU de Grenoble et Professeur des Universit\u00e9s en Pneumologie de l&#8217;Universit\u00e9 Grenoble Alpes.<\/p>\n<p class=\"bodytext\">Il a fait ses \u00e9tudes de M\u00e9decine \u00e0 Grenoble, un Master de Sciences \u00e0 l&#8217;Universit\u00e9 de Montr\u00e9al, puis sa Th\u00e8se de Science au sein de l&#8217;unit\u00e9 Inserm1055, Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e.<\/p>\n<p>[\/vc_column_text]<div class=\"ins-toggle ins_toggle69d7dfa680056  \" data-uid=\"ins_toggle69d7dfa680056\"><div class=\"\"><div class=\"toggle_inner_wrap\"><div class=\"ins_toggle69d7dfa680056 ins-toggle-click \"><div id='ins-button-69d7dfa680057' class='ins-button-wrapper text-left 0px 0px  vc_custom_1586181714717 ' ><div class='ins_toggle_button'><a class='ins-button toggle-button text-white pc-border pc-bg btn-radius-default default btn-small  '><span>Voir plus<\/span><\/a><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {jQuery(\"head\").append(\"<style>#ins-button-69d7dfa680057.ins-button-wrapper {margin-top: 0px;}#ins-button-69d7dfa680057.ins-button-wrapper {margin-bottom: 0px;}<\/style>\")\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script><\/div><\/div><div id=\"ins_toggle69d7dfa680056\" class=\"toggle-class\"  style=\"display:none;\" >[vc_column_text]<\/p>\n<p class=\"bodytext\">Il est membre fondateur de l&#8217;European Institute of Systems Biology and Medicine \u00e0 Lyon en 2010.<\/p>\n<p class=\"bodytext\">Son centre d&#8217;int\u00e9r\u00eat principal est l&#8217;insuffisance respiratoire chronique grave. Dans ce contexte, il est impliqu\u00e9 dans la prise en charge des hypertensions pulmonaires au sein du centre de comp\u00e9tence r\u00e9gional Saint-Etienne, Grenoble, Lyon.<\/p>\n<p class=\"bodytext\">Sur le plan interventionnel, les effets de la r\u00e9habilitation nutritionnelle des insuffisance respiratoires chroniques avant, voire apr\u00e8s transplantation pulmonaire, repr\u00e9sente la partie la plus sp\u00e9cifique de son travail de recherche clinique qui s&#8217;int\u00e8gre r\u00e9solument dans la promotion de la m\u00e9decine syst\u00e9mique.<\/p>\n<p class=\"bodytext\"><b>Publications:<br \/>\n<\/b>1. Pison C, C. Chauvin, E. Fontaine, F. Catelloni, C. Keriel, B. Paramelle, X. Leverve.Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia. Am. J. Physiol-Endocrinol Met 1995 ; 31 : E965-73<\/p>\n<p class=\"bodytext\">2. Schwebel C, Pin I, Barnoud D, Devouassoux G., Brichon PY, Chaffanjon Ph, Chavanon O., Sessa C, Blin D. Guignier M., Leverve X, Pison Ch. Prevalence and consequences of nutritional depletion in lung transplant candidates. Eur Respir J2000 ; 16 : 1050-5<\/p>\n<p class=\"bodytext\">3. Cracowski JL, Cracowski C, Bessard G, P\u00e9pin JL, Bessard J, Schwebel C, Stanke-Labesque, Pison C. Increased lipid peroxydation in patients with pulmonary hypertension. Am J Respir Crit Care Med 2001 ; 164 :1038-42<\/p>\n<p class=\"bodytext\">4. Cano NJM, Pichard C, Roth H, Court-Fortun\u00e9 I, Cynober L, G\u00e9rard-Boncompain M, Cuvelier A, Jean-Pierre Laaban JP, Jean-Claude Melchior JCl, Rapha\u00ebl JCl, Pison CM and the Clinical Research Group of the Soci\u00e9t\u00e9 Francophone de Nutrition Ent\u00e9rale et Parent\u00e9rale. C-reactive protein and body mass index predict outcome in end-stage respiratory failure. Chest 2004 ; 126 : 540-6<\/p>\n<p class=\"bodytext\">5. Guerrero K, Wuyam B, Mezin P, Vivodtzev I, Vendelin M, Jean-Christian Borel, Rachid Hacini R, Chavanon O, Imbeaud S, Saks V, Pison C. Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R1144-54.<\/p>\n<p class=\"bodytext\">6. Auffray C, Adcock I.M., Chung K.F., Djukanovic R, Pison C, Sterk PJ. An Integrative systems -biology approach for understanding of pulmonary diseases. Chest 2010;137;1410-16<\/p>\n<p class=\"bodytext\">7. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaici A, Weitzenblum E, Cordier JF, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M; Eric Hachulla E, Cottin V, Degano B, Ja\u00efs X, Montani D, Souza R, Simonneau G. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation. 2010;122:156-163<\/p>\n<p class=\"bodytext\">8. Pison CM, Cano NJ, Ch\u00e9rion C, Caron F, Court-Fortune I, Antonini MT, Gonzalez-Bermejo J, Meziane L, Molano LC, Janssens JP, Costes F, Wuyam B, Similowski T, Melloni B, Hayot M, Augustin J, Tardif C, Lejeune H, Roth H, Pichard C; the IRAD Investigators. Multimodal nutritional rehabilitation improves clinical outcomes of malnourished patients with chronic respiratory failure: a randomised controlled trial. Thorax 2011; 66:953-60<\/p>\n<p class=\"bodytext\">9. Guzun R, Aguilaniu B, Wuyam B, Mezin P, Koechlin-Ramonatxo C, Auffray C, Saks, V,Pison C. Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease. Acta Physiol (Oxf). 2012 Jun;205(2):236-46<\/p>\n<p class=\"bodytext\">10. Pison C, Magnan A, Botturi K, S\u00e8ve M, Brouard S, Marsland BJ, Ernst F, Paprotka T, Deplanche K, Fritz A, Siroux V, Boissel J-P, Corris PA, Auffray C, Nicod LP and the SysCLAD consortium. Prediction of chronic lung allograft dysfunction: a systems medicine challenge. Eur Respir J 2013, in press<\/p>\n<p>[\/vc_column_text]<\/div><\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1584807143299{margin-bottom: 40px !important;}&#8221;][vc_column][vc_column_text]The PAH research group has an established reputation which has made it possible to build a network of collaborators, bringing together the best national and international researchers [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":16307,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-16335","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>National and international collaborators - 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