{"id":16272,"date":"2018-11-29T07:59:15","date_gmt":"2018-11-29T12:59:15","guid":{"rendered":"https:\/\/phrg.ca\/accueil\/"},"modified":"2021-03-18T11:46:54","modified_gmt":"2021-03-18T15:46:54","slug":"accueil","status":"publish","type":"page","link":"https:\/\/phrg.ca\/en\/","title":{"rendered":"Home"},"content":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1585075595073{margin-top: 60px !important;margin-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;15386&#8243; img_size=&#8221;full&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css=&#8221;.vc_custom_1603715045809{margin-bottom: 10px !important;}&#8221; link=&#8221;https:\/\/iucpq.qc.ca\/&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;16162&#8243; img_size=&#8221;115&#215;49&#8243; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css=&#8221;.vc_custom_1604064218345{margin-bottom: 10px !important;}&#8221; link=&#8221;https:\/\/www.ulaval.ca\/&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1585075313321{margin-top: 0px !important;}&#8221;][vc_column][rev_slider_vc alias=&#8221;Accueil-01-en&#8221;][\/vc_column][\/vc_row][vc_row gap=&#8221;10&#8243; equal_height=&#8221;yes&#8221; css=&#8221;.vc_custom_1585077759147{margin-top: 40px !important;margin-bottom: 80px !important;}&#8221;][vc_column][vc_empty_space height=&#8221;30px&#8221;]<div id='ins-heading-69e77578a46bf' class='section-heading ins-heading default default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Pulmonary Hypertension<\/h3><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_tta_tabs style=&#8221;insignia_tab_layout3 title-font&#8221; alignment=&#8221;center&#8221; active_section=&#8221;1&#8243;][vc_tta_section title=&#8221;The disease&#8221; tab_id=&#8221;the-disease&#8221;][vc_row_inner equal_height=&#8221;yes&#8221;][vc_column_inner width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;20px&#8221;][vc_single_image image=&#8221;16203&#8243; alignment=&#8221;center&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;5\/6&#8243;][vc_empty_space height=&#8221;10px&#8221;][vc_column_text]According to the World Health Organization (WHO), pulmonary hypertension (PH) is a chronic and progressive disease characterized by an increase in blood pressure in the pulmonary arteries that carry blood from the heart to the lungs. The increased pressure makes it harder for the heart to work, causing heart problems.<\/p>\n<p>Pulmonary hypertension is a complex vascular disease for which the range of treatments is limited;\u00a0mortality and morbidity in affected patients remain high.\u00a0It is therefore necessary to acquire a good understanding of the mechanisms responsible for the pathogenesis of this disease in order to be able to offer patients a better range of treatments.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=&#8221;Clinical definition&#8221; tab_id=&#8221;clinical-definition&#8221;][vc_row_inner equal_height=&#8221;yes&#8221;][vc_column_inner width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;20px&#8221;][vc_single_image image=&#8221;16205&#8243; alignment=&#8221;center&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;5\/6&#8243;][vc_empty_space height=&#8221;10px&#8221;][vc_column_text]Pulmonary hypertension (PH) is defined as an average pulmonary arterial pressure (PAP) of more than 20 mm Hg at rest. Pulmonary arterial hypertension (PAH) also requires a pulmonary artery occlusion pressure (PAPO) of less than 15 mm Hg and a pulmonary vascular resistance (PVR) of more than 240 dyne.sec \/ cm-5 (3 Woods units). These pressures are measured by cardiac catheterization.<\/p>\n<p>When PAH occurs on its own without a known cause, it is called idiopathic PAH. However, it is more commonly associated with other diseases such as connective tissue diseases, HIV infections, portal hypertension and hemoglobinopathies. Little is known about the pathogenesis of PH, but since many of its forms present similar histology, it is possible that they are linked by common pathophysiological mechanisms.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=&#8221;Our goal&#8221; tab_id=&#8221;our-goal&#8221;][vc_row_inner equal_height=&#8221;yes&#8221;][vc_column_inner width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;20px&#8221;][vc_single_image image=&#8221;16201&#8243; alignment=&#8221;center&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;5\/6&#8243;][vc_empty_space height=&#8221;10px&#8221;][vc_column_text]The aim of our Research Group is to identify these mechanisms and to develop new therapeutic approaches to combat PAH.<\/p>\n<p>The Group&#8217;s clinical trials are therefore focused on the outcome of the disease, its treatment and its prognosis.<\/p>\n<p>Basic and translational research projects focus on the use of molecular resources and biomarkers to identify new molecules for further investigation.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; gap=&#8221;10&#8243; equal_height=&#8221;yes&#8221; color_scheme=&#8221;white&#8221; css=&#8221;.vc_custom_1584718224175{margin-bottom: 120px !important;border-bottom-width: 0px !important;background-image: url(https:\/\/phrg.ca\/wp-content\/uploads\/Clariwell\/lab-home2-1.jpg?id=491) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_empty_space height=&#8221;40px&#8221;][vc_single_image image=&#8221;16210&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_empty_space height=&#8221;20px&#8221;]<div id='ins-heading-69e77578a46ef' class='section-heading ins-heading text-left default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>The group's mission<\/h3><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script><div id='ins-heading-69e77578a4719' class='section-heading ins-heading text-left default    '  style='margin-top:0; margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '><\/h3><h6 class='section-heading-subtitle title-font  default '>To improve the quality of life of patients with pulmonary hypertension by providing them with the best available care combined with innovative research.<\/h6><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_column_text css_animation=&#8221;none&#8221;]The Group is currently the reference for fundamental, translational and clinical research in pulmonary hypertension in Canada. The cutting-edge techniques available as well as the numerous international collaborations offer an exceptional universe for training and research.<\/p>\n<p>More specifically, the Group&#8217;s mission is to elucidate the pathogenesis of the disease, to identify the molecular mechanisms involved and to develop new therapeutic approaches.[\/vc_column_text][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row gap=&#8221;10&#8243; equal_height=&#8221;yes&#8221; css=&#8221;.vc_custom_1603218943454{margin-bottom: 0px !important;}&#8221;][vc_column][vc_column_text]<\/p>\n<h3 style=\"text-align: center;\">Innovative research<\/h3>\n<p style=\"text-align: center;\">a passionate research team that is becoming the reference for<br \/>\nfundamental, translational and clinical research in pulmonary hypertension<\/p>\n<p>[\/vc_column_text][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;]<div id=\"counter-69e77578a473f\" class=\"ins-counter-element text-center      ins-animated fadeInUp\" data-animation-delay=200 data-perc=\"53\"><div class=\"ins-counter-content\"><div class=\"ins-counter ins-counter-number title-font margin-10px-bottom font-weight-600\">53<\/div><div class=\"ins-counter-title margin-15px-bottom title-font  font-weight-600 letter-spacing-1\">principal investigators, coordinators and collaborators<\/div><p class='ins-counter-box-text'>Principal investigators, co-investigators, research coordinators and national and international collaborators<\/p><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {jQuery(\"head\").append(\"<style>#counter-69e77578a473f .ins-counter-number{font-size: 70px; 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line-height: 75px;}#counter-69e77578a476b .ins-counter-title{font-size: 18px; line-height: 23px;}#counter-69e77578a476b .ins-counter-icon{font-size: 34px; line-height: 39px;}#counter-69e77578a476b .ins-counter-number{color: #07a7e3;}#counter-69e77578a476b .ins-counter-title{color: #074575;}<\/style>\")\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;]<div id=\"counter-69e77578a478f\" class=\"ins-counter-element text-center      ins-animated fadeInUp\" data-animation-delay=200 data-perc=\"17\"><div class=\"ins-counter-content\"><div class=\"ins-counter ins-counter-number title-font margin-10px-bottom font-weight-600\">17<\/div><div class=\"ins-counter-title margin-15px-bottom title-font  font-weight-600 letter-spacing-1\">clinical trials<\/div><p class='ins-counter-box-text'>Ongoing clinical trials in pulmonary hypertension or fibrosis<\/p><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {jQuery(\"head\").append(\"<style>#counter-69e77578a478f .ins-counter-number{font-size: 70px; line-height: 75px;}#counter-69e77578a478f .ins-counter-title{font-size: 18px; line-height: 23px;}#counter-69e77578a478f .ins-counter-icon{font-size: 34px; line-height: 39px;}#counter-69e77578a478f .ins-counter-number{color: #07a7e3;}#counter-69e77578a478f .ins-counter-title{color: #074575;}<\/style>\")\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;]<div id=\"counter-69e77578a47b2\" class=\"ins-counter-element text-center      ins-animated fadeInUp\" data-animation-delay=200 data-perc=\"218\"><div class=\"ins-counter-content\"><div class=\"ins-counter ins-counter-number title-font margin-10px-bottom font-weight-600\">218<\/div><div class=\"ins-counter-title margin-15px-bottom title-font  font-weight-600 letter-spacing-1\">publications<\/div><p class='ins-counter-box-text'>Publications by our principal investigators and students since the creation of the group<\/p><\/div><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {jQuery(\"head\").append(\"<style>#counter-69e77578a47b2 .ins-counter-number{font-size: 70px; 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margin-bottom:0'><h3 class='section-heading-title margin-10px-top  default '>Research topics treated in our center<\/h3><\/div><script type=\"text\/javascript\">\n\t\t(function(jQuery) {\n\t\t\t\t\t})(jQuery);\n\t\t\t\t\t\t<\/script>[vc_row_inner gap=&#8221;20&#8243;][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text el_class=&#8221;textbox_home_subjects&#8221;]<\/p>\n<ul>\n<li style=\"padding: 10px 0px;\">Epigenetic alterations (methylation, acetylation, non-coding RNA, etc.) in the pathogenesis of pulmonary arterial hypertension<\/li>\n<li style=\"padding: 10px 0px;\">Mechanisms of adaptation to stress in pulmonary arterial hypertension<\/li>\n<li style=\"padding: 10px 0px;\">Bioenergetic remodeling in pulmonary arterial hypertension<\/li>\n<li style=\"padding: 10px 0px;\">The physiology of exercise in patients with pulmonary arterial hypertension<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text el_class=&#8221;textbox_home_subjects&#8221;]<\/p>\n<ul>\n<li style=\"padding: 10px 0px;\">Peripheral angiogenesis defects in pulmonary arterial hypertension<\/li>\n<li style=\"padding: 10px 0px;\">Mechanisms responsible for pulmonary hypertension secondary to idiopathic pulmonary fibrosis<\/li>\n<li style=\"padding: 10px 0px;\">The mechanisms responsible for pulmonary hypertension secondary to a pathology of the left heart<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner gap=&#8221;20&#8243;][vc_column_inner][vc_empty_space height=&#8221;30px&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;80px&#8221;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1585075595073{margin-top: 60px !important;margin-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;15386&#8243; 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